Effects of Upgrading From Right Ventricular Pacing to Cardiac Resynchronization Therapy and Comparison With Dual-Chamber Defibrillator
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 307
- 试验地点
- 1
- 主要终点
- All cause mortality and hospitalization for heart failure
研究概览
简要总结
Patients who consecutively underwent de novo CRT implantation, CRT upgrade, and DDDR ICD implantation at the Cardiology Clinic of Bursa Postgraduate Hospital between January 2019 and December 2023 according to the European Society of Cardiology (ESC) guideline criteria were included in the study.
详细描述
100 patients receiving de-novo CRT, 38 patients upgrading from RV pacing to CRT, and 169 patients receiving a DDDR-ICD implantation were included the study. Inclusion criteria were left ventricular ejection fraction lower than 35% and either QRS longer than 130ms for CRT groups or QRS≤120ms for the DDDR-ICD group. Primary endpoints were all-cause mortality and hospitalization for heart failure during a follow-up period extending up to 5 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •De novo CRT group:
- •Sinus rhythm,
- •age higher than 18,
- •EF lower than 35%,
- •New York Heart Association (NYHA) class II-IV,
- •QRS >130 ms,
- •patients with atrial fibrillation (AF) who converted to sinus rhythm and who remained symptomatic despite 3-6 months of guideline-directed medical therapy.
- •CRT upgrade group:
- •Sinus rhythm,
- •age higher than 18,
- •EF lower than 35%,
- •NYHA class II-IV,
- •QRS duration >130 ms with RV pacing,
- •> 20% RV pacing rate,
- •patients with AF who converted to sinus rhythm, at least 6 months since pacemaker implantation, and symptomatic despite 3-6 months of guideline directed medical therapy.
- •DDDR ICD group:
- •Sinus rhythm,
- •age higher than 18,
- •EF lower than 35%,
- •QRS ≤120 ms,
- •NYHA class II-IV,
- •patients with AF converted to sinus rhythm,
- •receiving guideline-directed medical therapy.
排除标准
- •patients with atrial fibrillation
- •LV EF higher than 50 %
- •NYHA Class 1
- •Patients with active infection or cancer
结局指标
主要结局
All cause mortality and hospitalization for heart failure
时间窗: 24 months
次要结局
未报告次要终点
研究者
Hasan ARI
Professor Doctor
Bursa Postgraduate Hospital