Release of endogenous ligands of Toll-like receptors type 4 during mechanical ventilation in surgical patients with healthy lungs
- Conditions
- ventilator-induced lung injury1002766510024967
- Registration Number
- NL-OMON32393
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Between 18-65 years old, American Society of Anesthesiologists (ASA) status 1 or 2, ability to speak Dutch, no (N)SAID intake within 36 hours prior to surgery, no history of drug dependency or abus, body weight between 60-100 kg with a BMI <30 kg/m2.
Exclusion Criteria
Patients with pulmonary, cardiac, hepatic or renal disease or significant or instable disease of the central nervous system, patients that smoke, use of (N)SAIDs within 36 hours prior to surgery, history of drug dependence or drug abuse, BMI > 30 kg/m2 or <20 kg/m2.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The studied variable is the IL-8 concentration of the HEK293-TLR4 reporter<br /><br>assay after exposure to bronchotracheal aspirate. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>