To Compare The Efficacy Of Dexmedetomidine V/S Fentanyl In General Anesthesia Technique In Laparoscopic Surgeries

Phase 1/2

Completed

• Conditions: Acute appendicitis with generalized peritonitis,

• Registration Number: CTRI/2021/07/034882
• Lead Sponsor: Shilpa Sarang Kore

Brief Summary

Before induction patients will receive their respective drugs, drug preparation will be done by an anaesthesiologist who will not be involved in administration of anesthesia and patient care. The monitoring will be done by another doctor who is not involved in drug administration, data collection will be done by someone not involved in drug administration. The patients will receive their respective drugs as a loading dose over 10 mins, followed by at a rate of 0.2 mcg/kg/ hour throughout the surgery. Balanced general anaesthesia will be adopted for all patients. Once intubated, and pneumoperitoneum is attained parameters are monitored at serial intervals and blood samples are analyzed by glucometer for blood glucose level. Various adverse effects will be observed.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-17
• Last Update Posted: 2023-02-21

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

patients undergoing elective laparoscopic surgeries patients undergoing elective laparoscopic surgeries under general anaesthesia haemodynamically stable patients with routine investigations within normal limits without any other comorbidities availability of informed written consent.

Exclusion Criteria

• Patient refusal Patients with ASA III or more Age below 18 years and above 60 years patients posted for emergency surgeries patients who are on drugs that can influence hemodynamic and autonomic functions.
• patients with predictably difficult airway or difficult intubation history of cardiac disease and neurologic disease pregnancy and breast feeding women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Compare the efficacy of dexmedetomidine v/s fentanyl based general anaesthesia technique in attenuating neuroendocrine and hemodynamic stress response in laparoscopic surgeries.	Every 5 minutes post intubation

Secondary Outcome Measures

Name	Time	Method
To study the effects of dexmedetomidine and fentanyl on hemodynamic parameters during perioperative period	Every five minutes post intubation
to investigate the effects of dexmedetomidine and fentanyl on modulation of neuroendocrine stress response during elective laparoscopic surgeries	half an hour post intubation, 2 hours post extubation
Observe side effects of dexmedetomidine and fentanyl and their management	Anytime after administrating drugs until 24 hours post op

Trial Locations

Locations (1)

DY Patil Medical College and research centre; 🇮🇳 Pune, MAHARASHTRA, India

DY Patil Medical College and research centre

🇮🇳Pune, MAHARASHTRA, India

Dr Shilpa Sarang Sale

Principal investigator

09767002436

shilpasale@gmail.com