Intravenous dexamethasone in acute management of vestibular neuronitis: a prospective single centre randomised placebo controlled trial

niversity Hospital Centre Zagreb (Croatia)0 个研究点目标入组 100 人开始时间: 2011年3月31日最近更新: 2019年2月11日

试验速览

•Patients older than 18 years of age (either sex) who will be diagnosed as vestibular neuronitis in the emergency neurology department based on the following criteria:
•1. Persistent rotatory vertigo which started up to 48 hours
•2. Horisontal-torsional nystagmus, unidirectional, more pronounced on removing fixation
•3. Positive head thrust test on the side of vestibular lesion
•4. Absence of skew deviation (assessed by Maddox rod test)
•5. Normal brain multi-slice computed tomography (MSCT)
•6. Normal electrocardiogram (ECG)
•7. Normal laboratory findings (complete blood count [CBC], prothrombin time [PT], activated partial thromboplastin time [APTT], blood glucose level, urea, creatinine, aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyl transferase [GGT], creatine kinase [CK], lactate dehydrogenase [LD])

•1. Loss of hearing
•2. Tinnitus
•3. Presence of any neurological deficit
•4. Medical history containing data of:
•4.1. Unregulated arterial hypertension
•4.2. Atrial fibrillation
•4.3. Diabetes mellitus
•5. Patients taking:
•5.1. Corticosteroids
•5.2. Benzodiazepines
•5.3. Patients who have contraindications for taking corticosteroids and benzodiazepines

发起方

niversity Hospital Centre Zagreb (Croatia)