Intravenous dexamethasone in acute management of vestibular neuronitis

Not Applicable

Completed

• Conditions: Vestibular neuronitis; Ear, Nose and Throat; Disorders of vestibular function

• Registration Number: ISRCTN84838161
• Lead Sponsor: niversity Hospital Centre Zagreb (Croatia)

Brief Summary

1. 2016 results in https://www.ncbi.nlm.nih.gov/pubmed/25919484 (added 18/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-03-31
• Study Completion: 2013-01-15
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients older than 18 years of age (either sex) who will be diagnosed as vestibular neuronitis in the emergency neurology department based on the following criteria:
1. Persistent rotatory vertigo which started up to 48 hours
2. Horisontal-torsional nystagmus, unidirectional, more pronounced on removing fixation
3. Positive head thrust test on the side of vestibular lesion
4. Absence of skew deviation (assessed by Maddox rod test)
5. Normal brain multi-slice computed tomography (MSCT)
6. Normal electrocardiogram (ECG)
7. Normal laboratory findings (complete blood count [CBC], prothrombin time [PT], activated partial thromboplastin time [APTT], blood glucose level, urea, creatinine, aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyl transferase [GGT], creatine kinase [CK], lactate dehydrogenase [LD])

Exclusion Criteria

1. Loss of hearing
2. Tinnitus
3. Presence of any neurological deficit
4. Medical history containing data of:
4.1. Unregulated arterial hypertension
4.2. Atrial fibrillation
4.3. Diabetes mellitus
5. Patients taking:
5.1. Corticosteroids
5.2. Benzodiazepines
5.3. Patients who have contraindications for taking corticosteroids and benzodiazepines

Study & Design

• Study Type: Interventional
• Study Design: Not specified