Atrial Fibrillation and Neuropathic Pain After Thoracotomy and Continuous Application of Magnesium Sulphate.

Not Applicable

Completed

• Conditions: Atrial Fibrillation; Neuropathic Pain
• Interventions: Drug: Magnesium sulphate

• Registration Number: NCT02008747
• Lead Sponsor: Dr. Horst Schmidt Klinik GmbH

Brief Summary

Atrial fibrillation and chronic neuropathic pain are adverse events occurring after posterolateral thoracotomy for lung resection. The continuous application of magnesium sulphate may have a prophylactic effect. The investigators record the incidence of atrial fibrillation during a seven day period after thoracotomy as well as the incidence of chronic neuropathic pain during a three months period, comparing one group with a continuous application of magnesium sulphate against one group without magnesium sulphate.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2012-02
• Study Completion: 2012-05
• Study First Submitted: 2013-11-27
• Status Verified: 2013-12
• Study First Submitted QC: 2013-12-07
• Last Update Submitted: 2013-12-07
• Study First Posted: 2013-12-11
• Last Update Posted: 2013-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 18 years or older
• posterolateral thoracotomy for lung parenchyma resection
• informed consent

Exclusion Criteria

• hypersensitivity for magnesium sulphate
• pre-existing atrial fibrillation
• participation in another trial
• pregnancy or breastfeeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Magnesium sulphate	Magnesium sulphate	The patients in this group underwent general anaesthesia with total intravenous anesthesia containing Remifentanyl (0,3 mg/kg ideal body weight/h), Propofol (4 mg/kg ideal body weight/h) and Atracurium. They also received 40mg/kg ideal body weight magnesium sulphate by bolus injection before the operation started, followed by a continuous application of 10mg/kg ideal body weight/hour for 24 hours.

Primary Outcome Measures

Name	Time	Method
Incidence of atrial fibrillation	Up to 168 hours after operation	The incidence of atrial fibrillation was recorded using a 12 lead ECG for a period of 7 days after operation

Secondary Outcome Measures

Name	Time	Method
Chronic neuropathic pain	Three months	The incidence of neuropathic pain was recorded using the LANSS Score during a period of three months after posterolateral thoracotomy for lung resection.

Trial Locations

Locations (1)

HSK; 🇩🇪 Wiesbaden, Germany