Digestive Events in Duchenne Muscular Dystrophy Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of digestive events
研究概览
简要总结
Relation between clinical and genetic features and acute digestive events in Duchenne muscular dystrophy patients
详细描述
Clinical Data of the disease Digestive events (pseudo occlusion, gastrostomy, cholecystectomy) Nutritionnal parameters Genetic of dystrophin (approved genetic nationnal Data base, CHU Cochin, Paris France)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •all Duchenne muscular dystrophy patients in our center
排除标准
- 未提供
结局指标
主要结局
Incidence of digestive events
时间窗: 11 years
Clinical parameters (yes or no): gastrostomy, bowel occlusion, acute gastric paresia, biliary complication
Risk factors for digestive events (3)
时间窗: 11 years
echocardiography parameters (LVEF: left ventricular ejection fraction in %)
Risk factors for digestive events (2)
时间窗: 11 years
pulmonary functional tests (vital capacity in ml/kg)
Prevalence of digestive events
时间窗: 11 years
Clinical parameters (yes or no) : gastrostomy, bowel occlusion, acute gastric paresia, biliary complication
Risk factors for digestive events (4)
时间窗: 11 years
residual dystrophin level (Western blot and/or immunohistochemistry in muscle)
Risk factors for digestive events (1)
时间窗: 11 years
age (years)
Risks factors for digestive events (5)
时间窗: 11 years
genetic parameters (type of mutation, functional domain of altered dystrophin)
次要结局
- Nutritional status (1)(11 years)
- Nutritional status (2)(11 years)
研究者
Crenn
Professor
Centre d'Investigation Clinique et Technologique 805