THE EFFECT OF REPEATED REMOTE ISCHEMIC PRECONDITIONING ON ENDOTHELIAL FUNCTION AND INNATE IMMUNE RESPONSES IN PATIENTS WITH END-STAGE RENAL DISEASE
Completed
- Conditions
- kidney disease patients with dialysis10003216
- Registration Number
- NL-OMON40693
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
• Patients with chronic kidney disease (CKD stage 4 or 5)
Exclusion Criteria
• The presence of a patent arterio-venous fistula (for dialysis)
• Simultaneous participation in another interventional study
• Impossibility to perform RIPC, due to pathology of both arms (for example, sclerodermia, dystrophy, recent trauma, chronic wounds)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The change in endothelial function after a 7-day intervention (measured as the<br /><br>brachial artery flow-mediated dilation for the primary objective and<br /><br>contra-lateral brachialartery flow-mediated dilation for the secondary<br /><br>objective).</p><br>
- Secondary Outcome Measures
Name Time Method <p>brachial artery endothelial function in the dominant arm after<br /><br>ischemia-reperfusion injury</p><br>