Effects of Aspirin on Emotional Reactivity, Memory, and Risk-taking
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 268
- 试验地点
- 1
- 主要终点
- Emotional Reactivity
研究概览
简要总结
The aim of this study is to determine whether the drug aspirin has effects on emotional reactivity, emotional memory, and risk-taking behaviors.
详细描述
The goal of this study is to determine if aspirin (acetylsalicylic acid) alters emotional reactions to emotion evoking pictures as well as memory for them. Using a double-blind parallel arm study, participants will receive either placebo or a pain-relieving dose of aspirin (500mg). One hour later they will complete 30 minutes of tasks. This will include ratings of emotional pictures and memory for them. The paradigm is similar to previous experiments done in this lab using other cyclooxygenase inhibitors: ibuprofen and acetaminophen (Durso, Luttrell, & Way, 2015; Psychological Science, https://doi.org/10.1177/0956797615570366). Risk taking on the Balloon Analogue Risk Task will also be assessed. Participants will be healthy young adult males at Ohio State University.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •At least 18 years old and biologically male
排除标准
- •Due to the use of aspirin in this study, women will be excluded from the study due to potential negative effects it may have on pregnancy
- •Participants will also be excluded for the following medical reasons:
- •Having an allergy to aspirin, other salicylates, or any other pain reliever/fever reducer.
- •Having or recovering from a viral infection such as the chicken pox or flu.
- •Having taken aspirin or another NSAID drug (aspirin, ibuprofen, naproxen, or others) within the last 8 hours or plan to take aspirin or another NSAID drug in the 8 hours after the end of the study.
- •Having more than three drinks of alcohol in the 8 hours after completion of the study.
- •Having asthma, hay fever, nasal polyps, or chronic respiratory disease.
- •Impaired liver/kidney or impaired cardiovascular circulation (renal vascular disease, congestive heart failure, volume depletion, major surgery, sepsis or major hemorrhagic events)
- •Active or severe liver or kidney disease.
- •An ulcer, history of ulcers or are prone to bleeding.
- •A history of blood clotting defects.
- •Severe anemia.
- •Taking any of the following drugs: A blood thinning anticoagulant (e.g. warfarin), Digoxin, An Angiotensin Converting Enzyme (ACE) Inhibitor, Methotrexate, An oral glucocorticoid (e.g. hydrocortisone),Valproic Acid, A Selective Serotonin Reuptake Inhibitor (SSRI; e.g. Prozac; Zoloft)
- •Have had stomach ulcers or bleeding problems.
- •Have stomach problems such as heartburn, upset stomach, or stomach pain that does not go away or reoccurs.
- •Surgery in the last week or will have a surgery in the next week.
- •High blood pressure.
- •Diabetes, gout, or arthritis.
- •Low uric acid or Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
研究组 & 干预措施
Placebo
Single dose of a 500mg placebo tablet.
干预措施: Placebo (Drug)
Aspirin 500MG
Single dose of a 500 mg aspirin tablet.
干预措施: Aspirin 500 MG (Drug)
结局指标
主要结局
Emotional Reactivity
时间窗: 1.5 hours
Changes in self-reported evaluations of valence on a 1 to 7 scale and felt reactions to emotional images on a 1-7 scale.
Memory
时间窗: 1.5 hours
Changes in memory for emotional pictures. After rating the images, the participants will be shown them again as well as new pictures and asked to indicate whether they have seen the picture before or not.
Risk-Taking
时间窗: 1.5 hours
We will measure the adjusted average number of pumps on the Balloon Analogue Risk Task.
次要结局
- Individual Differences(1.5 hours)
研究者
Baldwin Way
Associate Professor
Ohio State University