Disruption of memory reconsolidation of alcohol-related memory associations by propanolol - effects of alcohol and betablocker

Conditions: alcohol abuse
MedDRA version: 9.1Level: LLTClassification code 10001584Term: Alcohol abuse

Registration Number: EUCTR2007-005929-30-NL

Lead Sponsor: Maastricht University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: Male

Target Recruitment: 60

Inclusion Criteria

males
age >= 18
recent history of heavy alcohol use
15–50 European standard drinks per week (European standard drinks contain about 10 g pure alcohol)
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

No history of treatment for addiction.
No use of medication that may interact with alcohol.
No contra-indications for propranolol:
sick-sinussyndrome, second- and thirddegree atrioventriculair-block, hypotension, cardiogene shock, clinically relevant sinusbradycardie, asthma and othetr obstructive longdiseases or untreated hartfailure.

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Weakening of previous learned positive associations with alcohol by propranolol administered immediately upon retrieval of these associative memories.;Secondary Objective: ;Primary end point(s): 1. scores on computertasks, comparison of scores from placebo and propranolol treatment.<br>2. subjective craving-scores using VAS-questionaires after completion of the computertasks<br>

Secondary Outcome Measures