A Study on Effect of Oral Melatonin and Oral Clonidine on stability of Heart rate and blood pressure during administration of general anesthesia

Phase 3

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2020/10/028682
• Lead Sponsor: Paras Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Patients in age group of 20 to 60 years

2. ASA grade I or II

3. Elective surgery under general endotracheal anaesthesia

4. Multivariate risk index (MVRI) score less than 4

Exclusion Criteria

1. Patients less than 20 and more than 60 years of age

2. ASA grade III or IV

3. Anticipated difficult intubation

4. Body Mass Index (BMI) greater than 30 kilograms per meter square

5. Modified Mallampatti grade III or IV

6. MVRI equal to or more than 4

7. Emergency surgeries

8. Patient’s refusal to participate in the study

9. Patient receiving treatment with either of the study drug that is melatonin or clonidine; or having any known allergy to these drugs.

10. Patients receiving treatment for any cardiac illness, pregnancy, renal disease, liver disease, morbid obesity, bleeding disorder.

11. Patients on anti-hypertensives, oral hypoglycemics, anti-depressants, anti-convulsants, anti-psychotics, and birth control pills.

12. Pregnant and lactating females.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure, rate pressure product, and oxygen saturation.Timepoint: before drug administration, after 30 minutes of drug administration, before induction, immediately after intubation (0 minute), and 1,2,3,5,10 minutes following endotracheal intubation.

Secondary Outcome Measures

Name	Time	Method
propofol doseTimepoint: at the time of induction <br/ ><br>rescue doses during surgery;volume of inhalational anesthetic agentTimepoint: Every 15 minutes during surgery