Comparison of the effects of melatonin, vitamin C and oral clonidine on the patient's hemodynamic response during anesthesia and afterwards to pain in septorhinoplasty surgery.
- Conditions
- Determining the effect of oral melatonin, vitamin C and clonidine on the hemodynamic response to laryngoscopy and endotracheal intubation, the need for anesthetics and pain after septorhinoplasty..
- Registration Number
- IRCT20210222050463N2
- Lead Sponsor
- Ahvaz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 120
The age group is 18-40 years
Physical status I-II American Society of Anesthesiology
Candidate for general anesthesia and endotracheal intubationCommunity Verified icon
Physical status III and above American Society of Anesthesiology
History of cognitive and mental disorders (dementia, severe depression)Community Verified icon
Patients who take anti-anxiety, sedative, anti-psychotic or anti-epileptic drugs.
History of circadian rhythm disorders such as chronic fatigue syndrome and sleepiness
History of chronic pain syndromes
Body mass index more than 30 kg/m²
History of difficult airway (Cormack Lehan grade [1] 2 or higher) or more than one intubation attemptCommunity Verified icon
History of obstructive sleep apnea and severe asthmaCommunity Verified icon
History of drug or alcohol abuse
History of congestive heart failure, heart block or bradycardia
History of liver or kidney failure
History of allergic reaction to studied drugsCommunity Verified icon
Patients who have difficulty communicating.Community Verified icon
If the patient moves during laryngoscopy or intubation.Community Verified icon
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determining the effect of melatonin, vitamin C and oral clonidine on hemodynamic response. Timepoint: Continuously at baseline (T0), 120 minutes after study drug administration, upon entering the operating room (T1), after induction of anesthesia (T2), just before laryngoscopy and endotracheal intubation (T3), after Intubation at intervals of 1 minute (T4), 3 minutes (T5), 5 minutes (T6), 10 minutes (T7) and 15 minutes (T8). Method of measurement: Operating room monitoring device.
- Secondary Outcome Measures
Name Time Method Reducing the use of anesthetics and postoperative painCommunity Verified icon. Timepoint: During and after the operation. Method of measurement: VAS.