Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

Early Phase 1

Recruiting

• Conditions: Hepatectomy
• Interventions: Drug: Desflurane; Drug: Propofol, dexmedetomidine

• Registration Number: NCT05246371
• Lead Sponsor: Ain Shams University

Brief Summary

This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Detailed Description

Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity.

Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Study Timeline

• Study Start: 2021-06-01
• Primary Completion: 2021-11-01
• Study First Submitted: 2022-01-21
• Study First Submitted QC: 2022-02-16
• Study First Posted: 2022-02-18
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-15
• Last Update Posted: 2023-01-18
• Study Completion: 2023-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients American Society of Anesthesiologists physical status (ASA) I to II.
2. Patients Child Pugh classification A to B.
3. Both sexes.
4. Aged between 18 years and 70 years
5. Scheduled for more than 1 segment hepatectomy.

Exclusion Criteria

1. Patients with Child Pugh classification C.
2. Patients younger than18 years old or older than 70 years old
3. Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
4. Prior liver resection for donation.
5. Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
6. Hypersensitivity to any of the used drugs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
desflurane	Desflurane	Patients will receive maintenance of general anesthesia by desflurane.
propofol and dexmedetomidine	Propofol, dexmedetomidine	Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine

Primary Outcome Measures

Name	Time	Method
bilirubin	1 week	bilirubin
albumin	1 week	albumin
aspartate aminotransferase (AST)	1 week	aspartate aminotransferase (AST)
alanine aminotransferase (ALT)	1 week	alanine aminotransferase (ALT)
prothrombin time	1 week	prothrombin time
INR	1 week	INR

Trial Locations

Locations (1)

Ain Shams University; 🇪🇬 Cairo, Egypt