Cerebellum - Cognitive Outcome and Functional Connectivity

Completed

• Conditions: Childhood Cerebellar Tumor

• Registration Number: NCT01730274
• Lead Sponsor: Medical University of Vienna

Brief Summary

Aim: To investigate the effect of cerebellar tumor surgery on the resting state functional connectivity level in higher order cognition networks known to interact with the cerebellum. Furthermore, to correlate the connectivity level of these networks with the neuropsychological performance and functional outcome of the patients.

The investigator's hypothesis is that the functional connectivity of various cognition networks in the cerebrum as assessed by resting-state functional magnetic resonance imaging can be impaired after cerebellar tumor surgery and can be correlated with the neuropsychological performance. The effect of surgery on the cognition networks and the neuropsychological performance is dependent on the tumor location within the cerebellum. Such a correlation seems feasible as functional connectivity analysis could be correlated with the neuropsychological impairment in various neuropsychiatric disorders. Furthermore, investigators were able to depict the maturation of the functional connectivity networks in parallel to the neurocognitive development in childhood

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-11-15
• Study First Submitted QC: 2012-11-20
• Study First Posted: 2012-11-21
• Study Start: 2013-01
• Primary Completion: 2014-09
• Study Completion: 2015-02
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-22
• Last Update Posted: 2021-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• • Male or female patients aged > 15 yrs

  • Age at surgery between 1 yrs - 12 yrs
  • Compliance (the patients have to be able to lay motionless in a 3 Tesla MR scanner and to cooperate with the examiner during the examination)
  • Signed informed consent from the patient and/or the parents

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Exclusion Criteria

• • Patients with Neurofibromatosis 1

  • Severe visual or auditory impairment
  • Cerebrospinal fluid shunt device
  • Prior radiotherapy or chemotherapy
  • Contraindications to MRI

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
neuropsychological assessment	up to 24 months

Trial Locations

Locations (1)

MUV, Department of Neurosurgery; 🇦🇹 Vienna, Austria