Comparision of treatment of bony defect with bone graft versus bone graft autologus blood product.

Phase 4

Completed

Brief Summary: The primary clinical features of periodontitis are attachment loss, alveolar bone loss, pocket formation, gingival recession, tooth mobility and/or tooth migration. Angular bone loss leads to formation of intrabony defects. Conventional treatment such as Open Flap Debridement (OFD) often results in healing by long junctional epithelium and has very little potential in regeneration of periodontal tissues. Demineralized Freeze-Dried Bone Allograft (DFDBA) has the capacity to induce bone formation presumably due to exposure of Bone Morphogenetic Proteins (BMPs) and is considered to be Osteoinductive. Platelet Rich Fibrin (PRF) was first made by Choukroun et al.8 PRF is an autologous, inexpensive and regenerative biomaterial. It contains various growth factors released by platelets and matrix proteins. changing the centrifugation protocol by decreasing speed and increasing centrifugation time (1500 rpm,14 minutes) leads to formation of a different form of fibrin known as Advanced-Platelet Rich Fibrin(A-PRF). Knowing the role of A-PRF and DFDBA in regeneration, the present study is an attempt to evaluate and compare the regenerative potential of A-PRF and DFDBA in the treatment of intrabony defects.

Recruitment & Eligibility

Inclusion Criteria

Patients with chronic periodontitis exhibiting intrabony defects.

Exclusion Criteria

Patients with contraindication to periodontal surgery & local anesthesia.
Any systemic disease affecting the bone density and outcome of periodontal therapy.
Smokers, alcoholics, and patients with other adverse habits.
Pregnant, nursing and menopausal women.
Any known allergy/ hypersensitivity to any product used in this study.
Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing.
Patients taking any anti-platelet and anticoagulant medication.
Patients who have undergone periodontal treatment within a period of past 1 year.

Primary Outcome Measures

Name	Time	Method
radiographic bone fill	baseline,6 months

Secondary Outcome Measures

Name	Time	Method
probing pocket depth	baseline,6 months
clinical attachment level	baseline,6 months

Locations (1): M.M. College of Dental Sciences and Research Mullana, Ambala.
🇮🇳
Ambala, HARYANA, India
M.M. College of Dental Sciences and Research Mullana, Ambala.
🇮🇳Ambala, HARYANA, India
Priyanka Kumari
Principal investigator
9131870427
princesscute.2527@gmail.com