Functional sympatholysis in heart failure: role of reactive oxygen species

Withdrawn

• Conditions: decompensatio cordis; heart decompensation; heart failure; 10019280

• Registration Number: NL-OMON38976
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Patients:
- Patients diagnosed with heart failure NYHA class II/III
- >= 18 years of age
- Mentally able/allowed to give informed consent;Controls:
- Subjects free of cardiovascular disease and/or cardiovascular medication
- >= 18 years of age
- Mentally able/allowed to give informed consent

Exclusion Criteria

Controls:
Cardiovascular disease
The use of cardiovascular medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>magnitude of decline in the combined oxygenated hemoglobin (HbO2) and myoglobin<br /><br>(MbO2) signal from the near-infrared spectroscopy during the cold pressor test<br /><br>at rest and during handgrip exercise at 10 and 30% MVC combined with the cold<br /><br>pressor test.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Brachial artery blood flow (using non-invasive ultrasound as a secondary<br /><br>measure of exercise-induced blood flow during handgrip and performance of the<br /><br>cold pressor test)<br /><br>- Mean arterial blood pressure (Nexfin, contra-lateral arm) (to control for<br /><br>potential differences in the blood pressure response between the subsequent<br /><br>tests)<br /><br>- Forearm blood flow using plethysmography (contra-lateral arm)</p><br>