Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure

Phase 4

• Conditions: Chronic Renal Failure
• Interventions: Drug: N-acetylcysteine

• Registration Number: NCT00716001
• Lead Sponsor: Osaka General Medical Center

Brief Summary

This study is to evaluate the efficacy of sodium bicarbonate plus N-acetylcysteine for the prevention of contrast-induced nephropathy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-07
• Study Start: 2008-07
• Study First Submitted: 2008-07-02
• Study First Submitted QC: 2008-07-11
• Last Update Submitted: 2008-07-11
• Study First Posted: 2008-07-15
• Last Update Posted: 2008-07-15
• Primary Completion: 2009-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• patients with chronic renal failure(serum creatinine >1.1mg/dl) undergoing elective percutaneous coronary intervention

Exclusion Criteria

• administered with sodium bicarbonate and/or N-acetylcysteine and/or contrast media within 72 hours.
• pregnancy
• congestive heart failure
• allergy to sodium bicarbonate and/or N-acetylcysteine
• hemodialysis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NAC	N-acetylcysteine	-
nonNAC	N-acetylcysteine	-