Comparison of brain perfusion in rhythm control and rate control of persistent atrial fibrillation: Prospective randomized trial
- Conditions
- Diseases of the circulatory system
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
•Patients who recurred after DC cardioversion, and
•Patients with persistent Atrial fibrillation (20~80 Years old), and
•LA diameter < 55mm, and
•patients possible to anticoagulation and anti arrhythmic drug
1. Atrial fibrillation accompanied by severe cardiac deformities or hemodynamic effects of structural heart disease
2. Patients with severe new function disorder or CT imaging with contrast medium difficult
3.An additional cerebral perfusion CT examination due to repeated radiation exposure is inappropriate
4.Past atrial fibrillation High Frequency Electrodelectomy or maze surgery patients with past history
5. Patients with active internal bleeding
6.Adaptive therapy and anticoagulant insufficiency
7.Flammatic atrial fibrillation (Grade 2, Mechanical valve, mitral valve cosmetic surgery)
8. Cardiac blood rate < 30%
9.Cerring serious co-morbidities of the symptom
10. Patients with an expected survival period of less than one year
11.Patients who are addicted to drugs or alcohol
12.Patients judged by other researchers to be unfit to participate in a clinical trial
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function changes (K-MOCA:Korea-Montreal Cognitive Assessment) and cerebral perfusion CT (Brain perfusion CT)
- Secondary Outcome Measures
Name Time Method Composite events: all cause mortality, hospitalization rate, stroke rate, heart failure rate, and major cardiovascular complications incidence rates;Comparison of actual rhythm control (On treat analysis);Comparison of incidence of side effects during antiarrhythmic or anticoagulant therapy;Comparison of Frequency and Complication Rate of High Frequency Electrode Ceramic Resection