Donepezil for Visuospatial dysfunction in Mild Cognitive Impairment
- Conditions
- Diseases of the nervous system
- Registration Number
- KCT0006236
- Lead Sponsor
- Jeonbuk National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 70
1. =60 and <90 years of age
2. Mild cognitive impairment (Peterson Criteria)
3. More than 6 years of education (more than elementary school graduation)
4. Normal visual acuity
5. Completion of a dementia work-up including neuropsychological tests and MRI
6. Amyloid PET scan positive
7. K-MMSE =19 points
1. Structural lesions
(such as territorial infarction, intracranial haemorrhage, brain tumour, hydrocephalus)
2. Severe white matter hyperintensities (WMH) observed on brain MR image
(severe WMH on MRI was defined as a cap or a band =10?mm as well as a deep white matter lesion =25?mm as modified from the Fazekas ischemia criteria)
3.When the following drugs are administered: rivastigmine, galantamin, and memantine among Cholinesterase inhibitors
4. Patients with neurological abnormalities that may cause memory impairment on medical examination
5. Persons with a history of one-axis psychiatric disorders, including intellectual disabilities, schizophrenia, alcoholism, and bipolar desorder
6. Those who have a history of malignant diseases(cancer) within the last 3 years. However, Cerviacl Carcinoma in Situ or Nonmelanoma Skin Cancer is excluded.
7. Those who have undergone cerebrovascular surgery such as brain surgery or carotid artery surgery
8. Those who have difficulty breathing when sitting still
9. Those who have had a memory disorder, language disorder, or problem solving ability disorder for more than 2 hours after a heart attack
10. Persons with a history of hospitalization for mental or emotional problems within the last 5 years
11. Those with a history of abuse of drugs within the last 5 years
12. Those with a history of receiving treatment for alcoholism within the last 5 years
13. Those who have lost consciousness for more than 1 hour due to causes other than general anesthesia
14. Those who have been hospitalized for a head injury
15. Those who are unable to read ordinary letters even with glasses due to decreased vision
16. Those who have difficulty understanding conversations due to hearing impairment even when wearing hearing aids
17. Those who determine that the investigator is unsuitable for participation in the clinical trial
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Eye-tracking metrics
- Secondary Outcome Measures
Name Time Method Cognitive function test result;Digital pen data