Can a ketone drink improve exercise performance in patients with Parkinson's disease?
Not Applicable
Completed
- Conditions
- Parkinson’s diseaseNervous System Diseases
- Registration Number
- ISRCTN16599164
- Lead Sponsor
- TdeltaS Ltd
- Brief Summary
2020 results in https://pubmed.ncbi.nlm.nih.gov/33100965/ (added 17/02/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
1. Diagnosis of Parkinson's disease
2. Hoehn and Yahr stages 1-2
3. Fluent in English
4. Capable of giving informed consent
5. Aged 40-80 years
Exclusion Criteria
1. Communication impairments
2. History or indications of cardiovascular disease
3. Any other disorder that the Principal Investigator deems may bias the study results or put the participant at risk
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Time to exhaustion (Te)<br> 2. Maximum wattage achieved by participants (Wmax)<br> 3. Maximum heart rate (HRmax) assessed by heart rate monitor worn during the test<br> 4. Oxygen consumption (VO2max) assessed using a respiratory gas capture face mask worn during the test<br> 5. Respiratory exchange ratio (RER) assessed using respiratory gas capture face mask worn during the test.<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Blood glucose level<br> 2. Blood lactate level<br> 3. Blood free fatty acid level<br> 4. Blood beta-hydroxybutyrate level<br> These will be measured using samples taken from a venous cannula inserted into one of the participants’ arms immediately before consuming the study drink, immediately before exercise (30 minutes after consuming the study drink), and immediately after exercise.<br>