The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise
- Conditions
- Exercise Metabolism
- Registration Number
- NCT06746805
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 27
- 18-50 years of age
- Trained cyclist/triathlete (VO2peak > 55 ml/kg/min for males and >48 ml/mg/min for females)
- Healthy as per medical history and investigator's/physician's judgement
- Having given written informed consent
- Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteroids)
- Smoking
- Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus)
- Diagnosed musculoskeletal disorders
- Adhering to a carbohydrate restrictive diet
- Participation in another study at the same time
- Blood donation in the 2 months before the first experimental trial
- Plasma donation in the 2 weeks before the first experimental trial
- Males: VO2peak <55 ml/min/kg body mass
- Females: VO2peak <48 ml/min/kg body mass
- Females: pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Exogenous carbohydrate oxidation rate Acute:during 3 hours of exercise Exogenous carbohydrate oxidation rate during exercise measured by 13C enrichment in breath. CHO+KETONE vs CHO+PLACEBO condition
- Secondary Outcome Measures
Name Time Method Endogenous carbohydrate disappearance rate Acute:during 3 hours of exercise Endogenous carbohydrate disappearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Exogenous carbohydrate disappearance rate Acute:during 3 hours of exercise Exogenous carbohydrate disappearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Total carbohydrate disappearance rate Acute:during 3 hours of exercise Total carbohydrate disappearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Exogenous carbohydrate appearance rate Acute:during 3 hours of exercise Exogenous carbohydrate appearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Endogenous carbohydrate appearance rate Acute:during 3 hours of exercise Endogenous carbohydrate appearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Total carbohydrate appearance rate Acute:during 3 hours of exercise Total carbohydrate appearance rate during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Plasma glucose enrichments during exercise Acute:during 3 hours of exercise Plasma glucose enrichments during exercise measured by stable isotope tracer methodology. CHO+KETONE vs CHO+PLACEBO condition
Related Research Topics
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Trial Locations
- Locations (1)
Maastricht University Medical Center+
🇳🇱Maastricht, Limburg, Netherlands