The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists

Not Applicable

Completed

• Conditions: Ketosis; Exercise
• Interventions: Dietary Supplement: Ketone monoester; Other: Placebo

• Registration Number: NCT05226962
• Lead Sponsor: McMaster University

Brief Summary

Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Participants will perform two trials in a randomized order. Each trial will involve a 20-minute bout of cycling on a stationary ergometer. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Detailed Description

This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Trained participants with competitive cycling experience will be recruited. Exercise will involve a 20-minute bout of cycling on a stationary ergometer with the goal of producing the highest power output possible. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Study Timeline

• Study First Submitted: 2022-01-27
• Study First Submitted QC: 2022-01-27
• Study First Posted: 2022-02-07
• Study Start: 2022-02-15
• Primary Completion: 2022-09-01
• Study Completion: 2022-10-01
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-04
• Last Update Posted: 2022-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Habitually ingesting >50 g of dietary carbohydrate daily i.e. not following a ketogenic diet.
• Regularly performing cycling exercise at least 3 days per week and for a total of ≥5 hours per week.
• Having an estimated peak oxygen uptake of ≥55 ml/kg/min for males and ≥48 ml/kg/min for females based on the online fitness calculator available at: www.worldfitnesslevel.org.
• Having competitive cycling experience.

Exclusion Criteria

• Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Ketone	Ketone monoester	An acute bout of exercise performed after the ingestion of a commercial ketone monoester supplement.
Control	Placebo	An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement.

Primary Outcome Measures

Name	Time	Method
Power output	20-minute measurement during exercise	Mean power output produced while cycling

Secondary Outcome Measures

Name	Time	Method
Blood glucose	20-minute measurement during exercise	Mean blood glucose while cycling
Perceived exertion	Single measurement immediately after exercise	Rating of perceived exertion while cycling
Blood ketone	Single measurement immediately prior to exercise	Blood ketone before exercise
Heart rate	20-minute measurement during exercise	Mean heart rate while cycling

Trial Locations

Locations (1)

McMaster University; 🇨🇦 Hamilton, Ontario, Canada