The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
- Conditions
- ExerciseKetosis
- Interventions
- Dietary Supplement: Ketone monoesterOther: Placebo
- Registration Number
- NCT05665855
- Lead Sponsor
- McMaster University
- Brief Summary
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency. Participants will perform three trials in a randomized order. Each trial will involve an incremental exercise protocol on a stationary cycle ergometer to volitional fatigue. Participants will ingest either a high or low dose of a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise efficiency.
- Detailed Description
This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency. Trained participants with cycling experience will be recruited. Participants will perform three trials in a randomized order. Each trial will involve a 3-minute warm-up followed by an incremental ramp test. The ramp will initially consist of three, 5-minute stages performed at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity. This will be followed by a further incremental ramp test to volitional fatigue. Participants will ingest either a high or low dose of a ketone supplement or a taste-matched placebo drink prior to exercise using a randomized, double-blind crossover design. Diet prior to exercise will be standardized between trials for a given participant. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise efficiency.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
- Be habitually consuming ≥50 g/d of carbohydrate (i.e., not following a ketogenic diet).
- Be engaged in endurance-type exercise >3h/wk.
- Have an estimated VO2peak of ≥90% for age and sex as estimated by an online calculator found at www.worldfitnesslevel.org.
- Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Ketone lower dose Ketone monoester An acute bout of exercise performed after the ingestion of a commercial supplement intended to provide \~0.3 g of ketone monoester per kg body mass of the participant. Control Placebo An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement. Ketone higher dose Ketone monoester An acute bout of exercise performed after the ingestion of a commercial supplement intended to provide \~0.6 g of ketone monoester per kg body mass of the participant.
- Primary Outcome Measures
Name Time Method Exercise efficiency Continuous measurement made over each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity Power output expressed relative to pulmonary oxygen uptake to determine cycling economy in watt per litre of oxygen per minute
- Secondary Outcome Measures
Name Time Method Heart rate Continuous measurement made over each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity Mean heart rate
Rating of perceived exertion Measurement made at the end of each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity Rating of perceived exertion measured using a 6-20 scale
Ketone body content in venous blood Measurement made immediately prior to exercise Mixed venous blood content of the ketone body beta-hydroxybutyrate
Trial Locations
- Locations (1)
McMaster University
🇨🇦Hamilton, Ontario, Canada