Effects of low-dose aspirin taken at bedtime on hypertensio
Completed
- Conditions
- Hypertension, aspirin, renin-angiotensin-aldosterone systemHypertensie, aspirine, renine-angiotensine-aldosteronsysteem
- Registration Number
- NL-OMON25788
- Lead Sponsor
- eiden University Medical CenterVascular Medicine UnitDepartment of General Internal Medicine and Endocrinology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. Essential hypertension, without treatment <160/100 mm Hg, with treatment <140/90 mm Hg. If treated, treatment should be stopped before entering into study.
2. Age 18-80 year
Exclusion Criteria
1. Moderate or severe hypertension (>160/100)
2. Secondary hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Renin-angiontensin-aldosterone system represented by renin activity
- Secondary Outcome Measures
Name Time Method Secondary endpoints are other determinants of RAAS-activity, markers of autonomous nervous system activity, COX-inhibition, vascular wall inflammation, vascular adhesion molecules and coagulation. We also measure 24-h blood pressure as well as central arterial stiffness (by non-invasive pulse wave analysis) to determine whether blood pressure effects are more centrally or peripherally located.