Effects of low-dose aspirin taken at bedtime on pathophysiologic mechanisms underlying hypertension in subjects with grade 1 essential hypertension: the Aspirin In Reduction of Tension (ASPIRETENSION) study

Phase 3

Completed

• Conditions: hypertensie; hypertension

• Registration Number: NL-OMON29702
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

-Essential hypertension, without treatment <160/100 mm Hg, with treatment <140/90 mm Hg. If treated, treatment should be stopped before entering into study.
-Age 18-80 year
-Capacity to give informed consent

Exclusion Criteria

-Moderate or severe hypertension (>160/100)
-Secondary hypertension
-Personal history of cardiovascular events
-Diabetes mellitus
-Rheumatoid arthritis
-Vasoactive medication
-Any contraindication to use of aspirin

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Renin-angiontensin-aldosterone system represented by renin activity. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are other determinants of RAAS-activity, markers of<br /><br>autonomous nervous system activity, COX-inhibition, vascular wall inflammation,<br /><br>vascular adhesion molecules and coagulation. We also measure 24-h blood<br /><br>pressure as well as central arterial stiffness (by non-invasive pulse wave<br /><br>analysis) to determine whether blood pressure effects are more centrally or<br /><br>peripherally located.</p><br>