Effects of low-dose aspirin taken at bedtime on blood pressure of subjects with who use aspirin for prevention of recurrent cardiovascular events: the Aspirin In Reduction of Tension II (ASPIRETENSION II) Study
Phase 3
Completed
- Conditions
- hypertensiehypertension
- Registration Number
- NL-OMON34181
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 250
Inclusion Criteria
patients who already use low-dose aspirin for secondary prevention of cardiovascular events and have a stable blood pressure (with or without therapy) of 149/94 or lower.
Exclusion Criteria
- blood pressure of 150/95 or higher
- change in blood pressure lowering medication within the last three months
- regular use of non-steroidal anti-inflammatory drugs (NSAID's)
- shift workers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Effect of aspirin intake at bedtime compared with intake at morning on blood<br /><br>pressure (24-h ambulatory blood pressure measurement)</p><br>
- Secondary Outcome Measures
Name Time Method <p>- the effect of aspirin at bedtime compared with aspirin at morning on platelet<br /><br>function<br /><br>- effects of different time of intake on potential side effects and compliance<br /><br>- potential effect modification of the effect on blood pressure by genes<br /><br>involved in blood pressure regulation</p><br>