Effects of low-dose aspirin taken at bedtime vs. on awakening on circadian rhythm of platelet function in healthy subjects

Phase 4

Completed

• Conditions: 10003216; 10035534; 10028593; arterial thrombosis

• Registration Number: NL-OMON38423
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-03-01
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 14

Inclusion Criteria

• Healthy subject
• Age >18yrs
• Capacity to give informed consent

Exclusion Criteria

• Active chronic disease
• Use of any other medication
• History of: major bleeding events, known bleeding diathesis or disorder, cardiovascular disease, malignancy
- allergy to salicylates
• Platelet count < 150 * 109/L
• VerifyNow Aspirin Reaction Units <550 ARU
• Smoking
• Shift work in the preceding 2 months
• Extreme chronotypes, defined as regular (>2 days/week) bedtime <22:00h or >24:00h and/or awakening <6:00h or >9:00h
• Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Platelet reactivity, measured by the VerifyNow® Aspirin Assay</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Platelet function and factors involved in coagulation pathways, measured in<br /><br>blood samples</p><br>