Mechanism based on Brain Age Analysis of Acupuncture Effect on DM-mild Cognitive Impairment: a multimodal functional MRI study

Not Applicable

• Conditions: DM-mild CognitiveImpairment

• Registration Number: ITMCTR2200006528
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

The inclusion criteria were as follows:1. T2DM-MCI Group: ?meet the diagnostic criteria of T2DM, age 45-65 years, male or female; ?meet the diagnostic criteria of MCI, MCI occurs after the diagnosis of T2DM; ?overall cognitive function is intact, i.e., MMSE score of 27-30; ?instrumental daily living ability is basically preserved, i.e., IADL=9 points/8 items; ?no dementia; ?right-hand dominance;?the patient and guardian jointly sign the informed consent. 2. T2DM-NC Group: ?meet the diagnostic criteria of T2DM, age 45-65 years old, male or female; ?no other medical history that may lead to cognitive impairment; ?no memory or other cognitive impairment; ?do not meet the diagnostic criteria of MCI or dementia; ?overall cognitive function is intact, i.e., MMSE 27-30 score; ?right-hand dominance; ?the patients themselves signed the informed consent. Enrollment matching: The age, gender and education of patients enrolled in T2DM-NC should be matched with those with mild cognitive impairment in type 2 diabetes, and the target of the group should be consistent in the duration of diabetes. 3. Healthy Control Group: ?no history of diabetes and other medical history that may lead to cognitive impairment; ? unstable mild memory loss or no memory or other cognitive impairment; ?do not meet the diagnostic criteria of MCI or dementia; ?overall cognitive function is intact, i.e., MMSE 27-30 score; ?right-handedness; ?the participants signed the informed consent. The age, gender and education of participants should be matched between groups.

Exclusion Criteria

The exclusion criteria were as follows:?cognitive impairment is known to be caused by reversible causes, such as VitB12 or folic acid deficiency or hypothyroidism; ?cognitive damage is caused by other irreversible causes, such as cerebrovascular disease, craniocerebral tumor, head trauma, poisoning, etc.; ?severe anxiety or depression (HAMD 17 items>24 points, HAMA>29 points), or other mental disorders; ?any severe history of alcohol abuse or drug dependency; ?have taken medications with side effects that affect cognition within a month?have taken sympathomimetic drugs, antihistamines, anti-anxiety drugs, and tranquilizers within 48 hours; have taken antipsychotic drugs within 72 hours before the evaluation;?unable to cooperate in completing the cognitive function assessment?there are metals in the body, or any other MRI contraindications.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
total intracranial volume (TIV);Reagional Homogeneity (ReHo);Degree Centrality (DC);Mini-mental State Examination (MMSE);Fractional anisotropy (FA);blood glucose level (0h/2h);cortical thickness;Montreal Cognitive Assessment (MoCa);ROI-functional connectivity(ROI-FC);HbA1c;