Impact of a low glycemic load diet ononcological course after surgical resection ofcolorectal liver metastases.

Not Applicable

Recruiting

• Conditions: C78.7; Secondary malignant neoplasm of liver and intrahepatic bile duct

• Registration Number: DRKS00033678
• Lead Sponsor: niklinik RWTH Aachen Allg.-, Viszeral-, Kinder & Transplantationschirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Metachronous colorectal liver metastases.
Fong score >= 4
Written informed consent to participate in the study.

Exclusion Criteria

- Type 1 diabetes mellitus
- Chronic renal failure (GFR <= 60 ml/min)
- Any factor that may limit the patient's ability to cooperate during the study (e.g., mental function or substance abuse)
- Significant cognitive impairment, clinically relevant or progressive disease (e.g., liver, kidney, cardiovascular, respiratory, vascular, brain, metabolic, thyroid) that could affect the course of the study.
- Concurrent participation in another AMG/MPG study
- Existing dependence on alcohol, medication, drugs or nicotine abuse during the fasting period
- Insufficient mental capacity to cooperate
- Eating disorders
- Kidney stones
- Fatty acid oxidation disorders
- Ketolysis/ketoneogenesis defects
- Gluconeogenesis defects
- Hyperinsulinism (e.g. nesidioblastoma)
- Pyruvate carboxylase deficiency
- Known bleeding tendency or use of anticoagulant medication (PTT, INR and platelets will be checked prior to study entry)
- Pregnancy and lactation
- Suspected noncompliance
- Special diet for medical reasons

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of the influence of a diet with a low glycemic load on the oncological course after surgical resection of colorectal liver metastases. For this over a period of 12 months, clinical imaging data are recorded at a total of 4 visits.

Secondary Outcome Measures

Name	Time	Method
Determination of the patient compliance with the change in diet.