Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study

Completed

• Conditions: Signs and Symptoms; Hypoxia-Ischemia, Brain
• Interventions: Device: Diffuse optical spectroscopy

• Registration Number: NCT01483495
• Lead Sponsor: University of California, Irvine

Brief Summary

The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.

Detailed Description

The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity.

Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.

Study Timeline

• Study First Submitted: 2011-08-02
• Study First Submitted QC: 2011-11-30
• Study Start: 2011-12
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Study First Posted: 2011-12-01
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-28
• Last Update Posted: 2022-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

1. Male or Female 20 years of age and older
2. Female non-pregnant
3. Subject scheduled for elective surgery under general anesthesia with intubation.
4. Subject who is able to give informed consent.

Exclusion Criteria

1. Less than 20 years old of age
2. Pregnant woman
3. Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diagnostic tool	Diffuse optical spectroscopy	Diffuse Optical Spectroscopy Imaging Cerebrovascular Reactivity

Primary Outcome Measures

Name	Time	Method
Brain blood flow	6 hours	Optical Imaging assess of Brain blood flow during surgical procedure

Trial Locations

Locations (1)

UCI Beckman Laser Institute; 🇺🇸 Irvine, California, United States