Respiratory Muscle Training in CF Patients

Not Applicable

Completed

• Conditions: Cystic Fibrosis; Respiratory Muscles
• Interventions: Other: Resistance inspiratory muscle training; Other: Endurance respiratory muscle training

• Registration Number: NCT03190031
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The present study aims at evaluating the effect of respiratory muscle training in adult patients with cystic fibrosis on lung function, exercise performance and quality of life.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-02-01
• Study First Submitted: 2017-06-12
• Study First Submitted QC: 2017-06-15
• Study First Posted: 2017-06-16
• Primary Completion: 2019-12-30
• Study Completion: 2019-12-30
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-19
• Last Update Posted: 2020-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Patients with a clinical diagnosis of cystic fibrosis
• Patients in steady state

Exclusion Criteria

• Patients during exacerbation
• Patients treated by oral corticotherapy (>0.5 mg/kg/j during >7 days) during the past 2 months
• Pregnant patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance inspiratory muscle training	Resistance inspiratory muscle training	The intervention consists in performing inspiratory resistive breathing at 70-80% of maximal inspiratory pressure for 20 min, 5 times a week, for 8 weeks
Endurance respiratory muscle training	Endurance respiratory muscle training	The intervention consists in performing isocapnic hyperpnea at 70-80% of maximal voluntary ventilation for 20 min, 5 times a week, for 8 weeks

Primary Outcome Measures

Name	Time	Method
Respiratory muscle endurance	Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)	Total breathing duration (in min) measured during an incremental hyperpnea test

Secondary Outcome Measures

Name	Time	Method
Respiratory muscle strength	Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)	Peak pressure (in mmHg) during maximal inspiratory and expiratory maneuvers
Maximal cycling performance	Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)	Peak maximal power output (in W) during an incremental cycling test
Quality of life of patients after the intervention	Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1)	Score obtained during the questionnaire CQF14+

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Grenoble, France