Anaesthesia and Tryptophan Pathway
- Conditions
- Tryptophan Pathway
- Registration Number
- NCT04466436
- Lead Sponsor
- Assiut University
- Brief Summary
Surgery has many immunomodulatory properties of which the mechanism is not clearly understood.
- Detailed Description
surgery and anesthesia have a deleterious effect on immune system,studyingtryptophan pathway might give more information on their effect.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
- elective surgery
Exclusion Criteria
- emergency surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method tryptophan metabolites in serum 72 hours
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link anesthesia to immune modulation via the tryptophan pathway?
How does tryptophan pathway inhibition compare to standard-of-care immunomodulatory treatments in surgical patients?
Which biomarkers could identify patients at risk for anesthesia-induced immune suppression through tryptophan metabolism?
What adverse events are associated with tryptophan pathway alterations during anesthesia and how can they be managed?
Are there combination therapies involving tryptophan pathway modulators that enhance post-surgical immune recovery?
Trial Locations
- Locations (1)
Assiut university
🇪🇬Assiut, Egypt
Assiut university🇪🇬Assiut, Egyptrasha hamed, MDContact0882413201rashaahmed11@yahoo.nom