The Impact of Exercise With Blood Flow Restriction: Sex and Age Differences on Physical Performance, Muscle Hypertrophy, and Blood Biomarkers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Muscle hypertrophy
研究概览
简要总结
The primary objective is to investigate whether six weeks of resistance training, in combination with blood flow restriction, produces a different adaptation in fat-free mass between males and females that are not physically active. The secondary objective is to compare changes in physical function, physical performance, and blood biomarkers between males and females following resistance training and blood flow restriction.
详细描述
Previous studies indicated a reduced workload (i.e., lifting lighter weight) combined with blood flow restriction leads to increased fat-free mass and muscle strength. However, females have been underrepresented in the blood flow restriction literature. Therefore, no study has investigated whether males and females of different age groups have different adaptations in fat-free mass, muscle strength, and performance outcomes following resistance training using blood flow restriction.
The primary objective will be to investigate sex differences in fat-free mass following six weeks of resistance training combined with blood flow restriction in young and older adults.
The secondary objective is to investigate sex differences in muscle strength, physical performance, and blood biomarkers between males and females following resistance training and blood flow restriction.
Briefly, participants between 19-30 years and 65 years and older will be recruited to participate in this study. Participants will present to the laboratory for two baseline testing visits interspersed with a minimum of four days. The first testing visit will include a variety of questionnaires, a blood draw, lipid and glucose, a dual-energy x-ray absorptiometry scan, anthropometrics, and a submaximal VO2. The second visit will include several physical function tests, such as the short physical performance battery and the Y-balance test, as well as a high-intensity isokinetic fatigue test using isokinetic dynamometry and 1-repetition maximum testing.
Upon completion of baseline testing, participants are enrolled in the exercise program. The first exercise session includes a blood draw before and immediately after the training session. This procedure will be duplicated at the final exercise session at the end of the six weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 19 and 100 years
- •Sedentary (not meeting physical activity guidelines), but otherwise healthy
排除标准
- •Aged outside the threshold
- •Uncontrolled hypertension
- •Presence of cardiovascular disease
- •Either surgery, bone fracture, or skin graft within the previous three months
- •Uncontrolled diabetes mellitus
- •Pregnancy
- •Individuals taking medications known to increase risk of blood clotting
结局指标
主要结局
Muscle hypertrophy
时间窗: Baseline and 6 weeks
Change in fat-free mass
次要结局
- Changes in physical function(Baseline and 6 weeks)
- Changes in blood biomarkers(Baseline and 6 weeks post-intervention and pre and post an acute bout of resistance training at baseline and and after 6 weeks)
- Muscle Endurance(Baseline and 6 weeks)
- Strength(Baseline and 6 weeks)
- Muscle Power(Baseline and 6 weeks)
研究者
Martin Senechal
Associate Professor, Martin Senechal, Ph.D.
University of New Brunswick