fNIRS Cortical Activation Patterns during Freezing of Gait.
Completed
- Conditions
- Parkinson's diseaseFreezing of Gait
- Registration Number
- NL-OMON27658
- Lead Sponsor
- Donders Institute for Brain, Cognition and Behaviour (Nijmegen)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
> 18 years old
- idiopathic Parkinson's disease
- experiencing freezing of gait more than once a day
Exclusion Criteria
- comorbidities that cause severe gait impairments
- comorbidities that interfere with fNIRS recording (i.e. previous brain surgery, structural cerebral lesions)
- inabilty to comply with the protocol (inability to walk 150 m or make a half turn unaided, inability to walk 10 seconds without experiencing freezing of gait, severe cognitive impairments)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in fNIRS activity (i.e. oxygenated hemoglobin and deoxygenated hemoglobin) relative to baseline in 10 regions of interest: the sensorimotor cortex, the supplementary motor area, the premotor cortex, the dorsolateral prefrontal cortex and the posterior parietal cortex (in both hemispheres).
- Secondary Outcome Measures
Name Time Method Motor scores: gait parameters derived from motion sensors, FOG severity, new FOG questionnaire score, MDS-UPDRS; <br>Cognitive scores: the MoCA score and Trail Making Test score;<br>Anxiety scores: the HADS scores and anxiety levels during the walking task.