Cortical activation patterns measured with functional near-infrared spectroscopy (fNIRS) during freezing of gait triggered by turning and passing doorways in Parkinson's disease.
Completed
- Conditions
- Parkinson's diseaseshaking palsy10028037
- Registration Number
- NL-OMON49479
- Lead Sponsor
- Radboud Universiteit Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
- idiopathic Parkinson's disease
- experiencing freezing of gait more than once a day
Exclusion Criteria
- comorbidities that cause severe gait impairments
- comorbidities that interfere with fNIRS recording (i.e. previous brain
surgery, structural cerebral lesions)
- inabilty to comply with the protocol (inability to walk 150 m or make a half
turn unaided, inability to walk 10 seconds without experiencing freezing of
gait, severe cognitive impairments)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is change in fNIRS activity (i.e. oxygenated<br /><br>hemoglobin and de-oxygenated hemoglobin) relative to baseline in 10 brain<br /><br>regions: the sensorimotor cortex, the supplementary motor area, the premotor<br /><br>cortex, the dorsolateral prefrontal cortex, and the posterior parietal (in both<br /><br>hemispheres).</p><br>
- Secondary Outcome Measures
Name Time Method <p>/</p><br>