Novel Evaluation of Aspirated Follicular Fluid

Not Applicable

• Conditions: Ovary Inflammation
• Interventions: Procedure: Ovum pickup

• Registration Number: NCT02999555
• Lead Sponsor: Meir Medical Center

Brief Summary

A molecular study of follicular fluid aspirated from ovarian follicles during routine in vitro fertilization treatment, after the eggs were identified and separated.

Detailed Description

Ovarian stimulation is a routine part of in vitro fertilization treatment: this process involves an inflammatory response in the developing follicles. We still do not completely understand the complex interactions leading to the maturation of the egg and the multiple interactions of the egg with its supporting cells. In this study we will assess follicular fluid, letf over after the eggs were identified and separated, for the presence of inflammatory mediators, dendritic cells , vasorin and soluble Flt1. The presence and quantification of these factors, as well as their correlation with the size of the aspirated follicle is the focus of this study.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2016-12-18
• Study First Submitted QC: 2016-12-20
• Study First Posted: 2016-12-21
• Study Start: 2017-02-01
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-09
• Last Update Posted: 2017-08-11
• Primary Completion: 2017-12
• Study Completion: 2018-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• All women going through a fertility/ fertility preservation indicated egg retrieval in the in vitro fertilization (IVF) unit in 'Meir medical center',
• Patients' informed consent

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Exclusion Criteria

• Patients refusing to take part in the study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Aspirated follicular fluid	Ovum pickup	Follicular fluid aspirated by follicle size and tested for the novel markers after eggs were identified and separated for the purpose of fertilization

Primary Outcome Measures

Name	Time	Method
Soluble Vasorin levels	24 hours post egg retrieval
Soluble Flt 1 levels	24 hours post egg retrieval
Dendritic cells quantification	24 hours post egg retrieval

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Saba, Israel