intravenous infusion of Lignocaine vs. dexmedetomidine given intraoperatively for reducing Acute Postoperative Pain After elective craniotomy Surgery
Not Applicable
Completed
- Conditions
- Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system
- Registration Number
- CTRI/2018/09/015598
- Lead Sponsor
- institute of neurosciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
1.ASA-I and II scheduled for elective craniotomy
2.Either sex
3.Age group 18 to 70 years
4.Preop GCS 15/15
5.No neuropsychiatric illness, alcohol or drug abuse
6.Co-operative and able to give informed consent in person.
Exclusion Criteria
1.ASA III and above
2.Age less than 18 years and more than 70 years
3.Preoperative GCS <15
4.Allergy to study drug
5.Severe respiratory, renal or hepatic disease
6. Psychiatric medical history
7.Severe hypotension (mean arterial pressure [MAP] <60 mmHg) or bradycardia (heart rate <40 bpm), arrhythmia, or urticaria due to lignocaine or dexmedetomidine infusion during the surgery
8.Patient requiring post-op mechanical ventilation (planned/unplanned)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method acute postoperative pain in the PACU using the numeric rating scale (NRS)Timepoint: postoperative
- Secondary Outcome Measures
Name Time Method complications including hypertension (systolic blood pressure more than 20% of baseline value), tachycardia (HR more than 100 beats/min) and PONV.Timepoint: postoperative;first requirement of postoperative analgesic (paracetamol, tramadol)Timepoint: postoperative;intraoperative consumption of propofol and fentanyl,Timepoint: inraoperative