Metabolic and Clinical Effect of Enteral Nutrition Therapy: Measured versus Estimated Energy Requirements in Critically ill Cirrhotic â?? A Randomized Controlled Trial - METALIC study

ICMR0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1.Eligible for enteral feeding with a functional gastrointestinal tract (with or without SPN)
•2.Mechanically ventilated patients expected to be on ventilator support for at least 5 days
•3.Expected length of ICU stay greater than 3 days
•4.Initiated on nutrition support (parenteral/or enteral nutrition)
•5.The diagnosis documented by physician within one day of ICU admit
•6. Signed informed consent

•1.Active upper gastrointestinal bleeding
•2.If there are conditions which precluded IC, such as an FiO2 >60 %, failure to cooperate, agitation, seizure activity, spasticity, or positive end-expiratory pressure (PEEP) >10 mmHg.
•3. Pregnant women
•4. Refused to consent/ inability to obtain informed consent
•5.Known long standing diabetic
•6. If there is any evidence of medical/surgical instability
•7. Hepatocellular carcinoma Extrahepatic malignancies
•8. Those receiving total parenteral (TPN)
•9. With persistent gastrointestinal dysfunction and ileus
•10. Readmitted to the ICU
•11. Terminally ill patients on high inotropic (triple) support
•12. Acute liver failure
•13. If there is any evidence of medical/surgical instability
•14. If patients are taking any portion of nutrition by mouth
•15. Patient on CRRT- continuous renal replacement therapy for more than 48 hours oICU admission
•16. Severe co morbidities such as CKD requiring maintenance dialysis, COPD ancardiac pathologies.
•17.Moribund patient with likely survival <24 hours
•18. Patients enrolled in other drug trials

发起方

ICMR