Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Early inflammation markers for VAP
研究概览
简要总结
In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.
详细描述
Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. In the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (Hb) synthesis is reduced. It has been reported that the ratio of reticulocyte / hemoglobin (Ret-He) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. In addition, the neutrophil / lymphocyte ratio (NLR) is a parameter studied in the hemogram panel. It provides a clue to both the presence of infection and the focus of the infection.
In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit
排除标准
- •Pulmonary or extrapulmonary infection before mechanical ventilation,
- •severe immunosuppression,
- •bleeding in the gastrointestinal system,
- •using corticosteroids,
- •neoplastic disease history
结局指标
主要结局
Early inflammation markers for VAP
时间窗: 7 days
To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.
次要结局
- morbidity and mortality(7 days)
研究者
Eylem Yaşar
Muğla Sıtkı Koçman University Department of Anesthesiology Specialist
Muğla Sıtkı Koçman University