Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

Completed

• Conditions: Ventilator-associated Pneumonia (VAP)

• Registration Number: NCT04620941
• Lead Sponsor: Muğla Sıtkı Koçman University

Brief Summary

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Detailed Description

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. In the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (Hb) synthesis is reduced. It has been reported that the ratio of reticulocyte / hemoglobin (Ret-He) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. In addition, the neutrophil / lymphocyte ratio (NLR) is a parameter studied in the hemogram panel. It provides a clue to both the presence of infection and the focus of the infection.

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Study Timeline

• Study First Submitted: 2020-11-03
• Study First Submitted QC: 2020-11-03
• Study First Posted: 2020-11-09
• Study Start: 2022-02-21
• Primary Completion: 2023-09-21
• Study Completion: 2023-12-21
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-04
• Last Update Posted: 2024-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

-Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit

Exclusion Criteria

• Pulmonary or extrapulmonary infection before mechanical ventilation,
• severe immunosuppression,
• bleeding in the gastrointestinal system,
• using corticosteroids,
• neoplastic disease history

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Early inflammation markers for VAP	7 days	To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.

Secondary Outcome Measures

Name	Time	Method
morbidity and mortality	7 days	To compare the effects of Ret-He and NLR values on morbidity and mortality with other inflammation markers

Trial Locations

Locations (1)

Mugla Sitki Kocman Universty; 🇹🇷 Muğla, Kötekli, Turkey