The effects of medication induced blood pressure reduction on cerebral hemodynamics in hypertensive frail elderly

Radboud University Medical Center0 sites12 target enrollmentJune 18, 2022

Overview

No summary available.

Registry

who.int

Start Date

June 18, 2022

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

•\- Age \=70 years.
•\- Clinical Frailty Scale \=4 and \=7\.
•\- Diagnosis of:
•Untreated systolic hypertension, i.e. office systolic blood pressure \=150 mmHg without antihypertensive treatment, or;
•Uncontrolled systolic hypertension, i.e. office systolic blood pressure \=150 mmHg despite antihypertensive treatment.
•\- Will be starting (untreated) or adding (uncontrolled) antihypertensive treatment in the near future for (further) reducing systolic blood pressure by \=10 mmHg while reaching a treatment target of office systolic blood pressure \=140 mmHg, with the indication of primary or secondary prevention of vascular events, judged by the treating physician (geriatrician or primary care physician)
•\- Able to understand and perform study related procedures.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) no

•\- Unable to provide signed and dated informed consent form.
•\- Mentally incompetent subjects (e.g. due to dementia) as assessed by a physician.
•\- Currently enrolled in another interventional study targeting either blood pressure and/or cerebral blood flow.
•\- Cardiovascular event within the past 3 months.
•\- Severe renal disease (eGFR \<25 ml/min).
•\- Known secondary cause of hypertension that causes safety concerns.