The effects of medication induced blood pressure reduction on cerebral hemodynamics in hypertensive frail elderly

Radboud University Medical Center0 个研究点目标入组 12 人开始时间: 2022年6月18日最近更新: 2023年9月18日

适应症

试验速览

暂无简介。

•- Age =70 years.
•- Clinical Frailty Scale =4 and =7.
•- Diagnosis of:
•Untreated systolic hypertension, i.e. office systolic blood pressure =150 mmHg without antihypertensive treatment, or;
•Uncontrolled systolic hypertension, i.e. office systolic blood pressure =150 mmHg despite antihypertensive treatment.
•- Will be starting (untreated) or adding (uncontrolled) antihypertensive treatment in the near future for (further) reducing systolic blood pressure by =10 mmHg while reaching a treatment target of office systolic blood pressure =140 mmHg, with the indication of primary or secondary prevention of vascular events, judged by the treating physician (geriatrician or primary care physician)
•- Able to understand and perform study related procedures.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range 0
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 12

•- Unable to provide signed and dated informed consent form.
•- Mentally incompetent subjects (e.g. due to dementia) as assessed by a physician.
•- Currently enrolled in another interventional study targeting either blood pressure and/or cerebral blood flow.
•- Cardiovascular event within the past 3 months.
•- Severe renal disease (eGFR <25 ml/min).
•- Known secondary cause of hypertension that causes safety concerns.

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