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A CLINICAL STUDY IN PRETERM NEONATES TO ASSES THE EFFECT OF BLOOD TRANSFUSION ON OXYGEN CONCENTRATION IN BRAIN AND GUT CIRCULATIO

Not Applicable
Conditions
Health Condition 1: D539- Nutritional anemia, unspecified
Registration Number
CTRI/2019/12/022463
Lead Sponsor
Deptt of Neonatology Sir ganga Ram Hospital
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
ot Yet Recruiting
Sex
Not specified
Target Recruitment
0
Inclusion Criteria

Neonates requiring RBC transfusion during their NICU stay as per Canadian Pediatric Society (CPS) guidelines

Exclusion Criteria

Following neonates will be excluded from study:

i.Neonates requiring invasive mechanical Ventilation and/or inotropic support.

ii.Intraventricular hemorrhage Grade II or more.

iii.Diagnosis of NEC at the time of transfusion.

iv.Major congenital anomalies

v.Parental refusal to participation in study

Study & Design

Study Type
Observational
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
i.To compare the regional cerebral regional oxygen saturation (crSO2) and splanchnic regional oxygen saturation (srSO2) using Near Infrared Spectroscopy (NIRS) before and after RBC transfusion in preterm neonates.Timepoint: i.To compare the regional cerebral regional oxygen saturation (crSO2) and splanchnic regional oxygen saturation (srSO2) using Near Infrared Spectroscopy (NIRS) before and after RBC transfusion in preterm neonates.
Secondary Outcome Measures
NameTimeMethod
i.Cerebral fractional tissue oxygen extraction (cFTOE) and splanchnic fractional tissue oxygen extraction (sFTOE) levels. <br/ ><br>ii.Heart rate, mean arterial blood pressure and proportion of time spent with saturation below 80%. <br/ ><br>Timepoint: i.Cerebral fractional tissue oxygen extraction (cFTOE) and splanchnic fractional tissue oxygen extraction (sFTOE) levels. <br/ ><br>ii.Heart rate, mean arterial blood pressure and proportion of time spent with saturation below 80%. <br/ ><br>
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