The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial
- Conditions
- Induced AbortionAnesthesia
- Interventions
- Registration Number
- NCT02208596
- Lead Sponsor
- Third Affiliated Hospital of Zhengzhou University
- Brief Summary
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
- Aged between 20 and 35 years
- American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ
- Singleton pregnancy and the gestational period is 6 to 8 weeks
- Expected operation duration is within 60 minutes
- The body weight should be within 15% around the standard weight
- Signed informed consent form
- Serious cardiac, cerebral, liver, kidney, lung, endocrine disease
- Upper respiratory infections within 4 weeks
- Long use of hormone or history of adrenal suppression
- History of use of glucocorticoids, aprotinin or immunosuppressant
- Manifestation of immunodeficiency
- History of use of sedatives or opiates
- Needs of Neuromuscular blocker (except intubation)
- Allergy to trial drug or other contraindication
- Pregnant or breast-feeding women
- Attended other trial past 30 days
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group A pentazocine In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group A propofol In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group B pentazocine In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group A Etomidate In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group C pentazocine In group C, propofol (1%) will be injected continuously until the eyelash reflex disappears. During the operation, supplementary propofol will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group B propofol In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group B Etomidate In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. Group C propofol In group C, propofol (1%) will be injected continuously until the eyelash reflex disappears. During the operation, supplementary propofol will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.
- Primary Outcome Measures
Name Time Method Heart rate From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection Heart rate will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
Blood pressure From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection Blood pressure will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
Pulse oxygen saturation From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection Pulse oxygen saturation will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate.
- Secondary Outcome Measures
Name Time Method Use of specific medications from the injection of propofol or mixture of propofol and etomidte to discharge from the hospital, expected to no more than 1 hour Dose of propofol or mixture of propofol and etomidate from the injection of propofol or mixture of propofol and etomidate to the last supplement of hypnotic agents, expected to be no more than 5 min Aldrete score 10 min after the opration Satisfaction degree of the patient, the surgeon and the anesthetist 10 min before discharge from the hospital Satisfaction degree will be rated as excellent, good and poor based on a scale of 1 to 10. Excellent is 8 to 10, good is 5 to 7 and poor is 1 to 4.
Efficacy of anesthesia from baseline to discharge from the hospital, expected to no more than 1 hour The following point-in-time will be recorded to calculated the period from the injection of propofol or mixture of propofol and etomidate: disappearance of eyelash reflex, injection of supplementary propofol or mixture of propofol and etomidate, awaking, obeying commands, discharge. Anesthesia time was defined as the period from disappearance of eyelash reflex to awaking.
Verbal rating scales of uterine contraction from 5 min after the operation to discharge from the hospital, expected to be no more than 1 hour Verbal rating scales of uterine contraction should be recorded at 5 min, 15 min after the operation and before discharge from the hospital