A Comparative Study Of PF-06439535 Plus Paclitaxel-Carboplatin And Bevacizumab Plus Paclitaxel-Carboplatin Patients With Advanced Non-Squamous NSCLC
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- Registration Number
- NCT02364999
- Lead Sponsor
- Pfizer
- Brief Summary
This is a multinational, double-blind, randomized, parallel-group Phase 3 clinical trial evaluating the efficacy and safety of bevacizumab-Pfizer plus paclitaxel and carboplatin versus bevacizumab-EU plus paclitaxel and carboplatin in first-line treatment for patients with advanced (unresectable, locally advanced, recurrent or metastatic) non-squamous NSCLC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 719
- Male and female patients age at least 18 years of age, or age of consent in the region.
- Newly diagnosed Stage IIIB or IV non-small cell lung cancer (according to Revised International System for Staging Lung Cancer criteria of 2010) or recurrent non-small cell lung cancer (NSCLC).
- Histologically or cytologically confirmed diagnosis of predominately non-squamous NSCLC.
- Be eligible to receive study treatment of bevacizumab, paclitaxel, and carboplatin based on local standard of care, for the treatment of advanced or metastatic non-squamous NSCLC.
- Small cell lung cancer (SCLC) or combination SCLC and NSCLC. Squamous-cell tumors and mixed adenosquamous carcinomas of predominantly squamous nature.
- Evidence of a tumor that compresses or invades major blood vessels or tumor cavitation that is likely to bleed.
- Known sensitizing EGFR mutations (for example, deletion 19 or L858R) or EML4-ALK translocation positive mutations.
- Prior systemic therapy for NSCLC; prior neoadjuvant or adjuvant therapy is allowed if surgical resection for primary disease was performed.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bevacizumab-Pfizer Paclitaxel Bevacizumab-Pfizer plus paclitaxel and carboplatin Bevacizumab-Pfizer Bevacizumab-Pfizer Bevacizumab-Pfizer plus paclitaxel and carboplatin Bevacizumab-EU Bevacizumab-EU Bevacizumab-EU plus paclitaxel and carboplatin Bevacizumab-Pfizer Carboplatin Bevacizumab-Pfizer plus paclitaxel and carboplatin Bevacizumab-EU Paclitaxel Bevacizumab-EU plus paclitaxel and carboplatin Bevacizumab-EU Carboplatin Bevacizumab-EU plus paclitaxel and carboplatin
- Primary Outcome Measures
Name Time Method Objective Response Rate (ORR) by Week 19 25 weeks ORR refers to percentage of participants who achieved complete response (CR) or partial response (PR) by Week 19 of the study in accordance with Response Evaluation Criteria in Solid Tumors (RECIST) v 1.1 which was subsequently confirmed by Week 25. A participant achieved CR if both target and non-target lesions achieved CR, no new lesions; achieved PR if target lesions achieved CR or PR, non-target lesions were assessed as non-CR/non-PD (progressive disease), indeterminate or missing, and no new lesions. For target lesions, CR: complete disappearance of all target lesions except nodal disease (target nodes must decrease to normal size); PR: \>= 30% decrease under baseline of the sum of diameters of all target measurable lesions. For non-target lesions, CR: disappearance of all non-target lesions and normalization of tumor marker levels and all lymph nodes must be normal in size; non-CR/non-PD: persistence of any non-target lesions and/or tumor marker level above the normal limits.
- Secondary Outcome Measures
Name Time Method Number of Participants With Neutralizing Antibody (NAb) 55 weeks Only samples that were confirmed positive for ADA were further tested for NAb. The NAb analysis was conducted using a single validated quasi-quantitative enzyme-linked immunosorbent assay (ELISA) that utilized PF-06439535 as a reagent. Samples with NAb titer \>=1.70 were considered positive.
Duration of Response (DOR) 55 weeks DOR was defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of PD or to death due to any cause in the absence of documented PD. DOR was based on the Brookmeyer and Crowley method.
Survival Rate at 55 Weeks 55 weeks This outcome measure refers to the possibility of being alive at 55 weeks since start of study treatment, estimated from the Kaplan-Meier curve using the product-limit method.
Serum Concentration of Bevacizumab up to 1 Year Pre-dose from Cycle 1 to Cycle 17, 2.5 hours post-dose in Cycle 1, and 1.5 hours post-dose in Cycle 5 Number of Participants With Anti-Drug Antibody (ADA) 55 weeks ADA assay was performed using a sensitive, specific, and semi-quantitative electrochemiluminescent (ECL) method, which used biotinylated- and ruthenium-labeled PF-06439535 as reagents. Samples with ADA titer greater than or equal to (\>=) 2.29 were considered positive.
Number of Participants With Laboratory Abnormalities (Without Regard to Baseline Abnormality) 55 weeks Laboratory evaluation included hematology (hemoglobin, white blood cells, platelets and absolute neutrophil count), blood chemistry (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, serum or plasma creatinine, sodium, potassium, total calcium, magnesium, blood urea nitrogen or urea, and albumin ), coagulation (international normalized ratio for prothrombin time and activated partial thromboplastin time) and urinalysis (dipstick followed by a quantitative urine protein analysis for results of 2+ or greater).
Number of Participants With Treatment-Emergent Adverse Events 55 weeks AE was defined as any untoward medical occurrence in a clinical investigation participant administered a product or medical device, regardless of the causal relationship to study treatment. Treatment-emergent AEs (TEAEs) were defined as AEs which occurred for the first time during the effective duration of treatment or AEs that increased in severity during treatment. Serious AEs (SAEs) were defined as any untoward medical occurrence at any dose that resulted in death; was life-threatening (immediate risk of death); required inpatient hospitalization or caused prolongation of existing hospitalization; resulted in persistent or significant disability/incapacity (substantial disruption of the ability to conduction normal life functions). AEs included SAEs and non-serious AEs. Causality to study treatment was determined by the investigator. Severity was graded according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.03.
Progression Free Survival Rate at 55 Weeks 55 weeks This outcome measure refers to the possibility of being progression free at 55 weeks since start of study treatment, estimated from the Kaplan-Meier curve using the product-limit method.
Trial Locations
- Locations (255)
Millennium Oncology
🇺🇸The Woodlands, Texas, United States
Sahyadri Clinical Research and Development Center (A Unit of Sahayadri hospitals Limited)
🇮🇳Pune, Maharashtra, India
Institute of Respiratory Diseases, SMS Medical College & Hospital
🇮🇳Jaipur, Rajasthan, India
The Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, Gauteng, South Africa
Beaver Medical Group, L.P.
🇺🇸Highland, California, United States
Phoebe Putney Memorial Hospital
🇺🇸Albany, Georgia, United States
Epic Pharmacy
🇦🇺Lismore, New South Wales, Australia
St. Joseph's Regional Medical Center
🇺🇸Paterson, New Jersey, United States
The Tweed Hospital
🇦🇺Tweed Heads, New South Wales, Australia
Instituto de Oncologia de Sorocaba - ONCO Clinicas Especializadas SC Ltda
🇧🇷Sorocaba, SAO Paulo, Brazil
Instituto COI de Pesquisa, Educacao e Gestao - COI Clinicas Barra Da Tijuca
🇧🇷Rio de Janeiro, Brazil
Complex Oncological Center Shumen EOOD
🇧🇬Shumen, Bulgaria
University Hospital Centre "Sestre Milosrdnice"
🇭🇷Zagreb, Croatia
Centro de Investigaciones Clinicas Vina del Mar Ltda.
🇨🇱Vina del Mar, V Region, Chile
Nemocnice na Plesi s.r.o
🇨🇿Nova Ves pod Plesi, Czechia
Nemocnice Novy Jicin a.s
🇨🇿Novy Jicin, Czechia
Lekarna Agel Novy Jicin
🇨🇿Novy Jicin, Czechia
Nemocnice Pelhrimov p.o, Radioterapeuticke oddeleni
🇨🇿Pelhrimov, Czechia
Lekarna Oblastni nemocnice Pribram
🇨🇿Pribram, Czechia
Centre Hospitalier General De Mont De Marsan
🇫🇷Mont De Marsan Cedex, France
Evangelische Lungenklinik Berlin
🇩🇪Berlin, Germany
Vivantes GmbH Apotheke des Humboldt-Klinikums
🇩🇪Berlin, Germany
Vivantes Klinikum Spandau
🇩🇪Berlin, Germany
Staedtisches Klinikum Braunschweig gGmbH Apotheke
🇩🇪Braunschweig, Germany
Staedtisches Klinikum Braunschweig gGmbH
🇩🇪Braunschweig, Germany
Apotheke Johannstadt Sven Ullrich e.K.
🇩🇪Dresden, Germany
Radiologie Nuklearmedizin Adickesallee
🇩🇪Frankfurt am Main, Germany
Sued-Apotheke
🇩🇪Frankfurt am Main, Germany
Asklepios Fachkliniken Muenchen Gauting
🇩🇪Gauting, Germany
Zytoservice Deutschland GmbH
🇩🇪Hamburg, Germany
Universitaetsklinikum des Saarlandes - Klinik fuer Innere Medizin V - Pneumologie, Allergologie,
🇩🇪Homburg/Saar, Germany
Friedrich-Ebert-Krankenhaus Neumuenster
🇩🇪Neumuenster, Germany
Radiologisches Institut Koblenz
🇩🇪Koblenz, Germany
Vincentius-Diakonissen-Kliniken gAG Zentralapotheke
🇩🇪Karlsruhe, Germany
Institut Fuer Versorgungsforschung In Der Onkologie
🇩🇪Koblenz, Germany
Vincentius-Diakonissen-Kliniken gAG Klinik fuer Diagnostische und Interventionelle Radiologie
🇩🇪Karlsruhe, Germany
Sonnenschein Apotheke
🇩🇪Koblenz, Germany
Zentrum fuer Radiologie und Nuklearmedizin am Johannisplatz (ZRN Leipzig)
🇩🇪Leipzig, Germany
POIS Leipzig GbR, Pneumologisch/onkologisch/internistisches Studienzentrum
🇩🇪Leipzig, Germany
General Oncology Hospital of Kifissia "Ag. Anargiroi"
🇬🇷Athens, Greece
University General Hospital Of Patras
🇬🇷Patras, Greece
Thermi Clinic S.A
🇬🇷Thessaloniki, Greece
Gen.Hospital "G. Papanikolaou"
🇬🇷Thessaloniki, Greece
Semmelweis Egyetem Klinikai Pulmonologiai Klinikai Gyogyszertar
🇭🇺Budapest, Hungary
Semmelweis Egyetem, Pulmonologiai Klinika
🇭🇺Budapest, Hungary
Csongrad Megyei Mellkasi Betegsegek Szakkorhaza
🇭🇺Deszk, Hungary
Petz Aladar Megyei Oktato Korhaz, Pulmonologiai Osztaly
🇭🇺Gyor, Hungary
Oncologia Medica, Fondazione Poliambulanza Instituto Ospedaliero
🇮🇹Brescia, BS, Italy
UOC di Oncologia Medica
🇮🇹Lido di Camaiore, LU, Italy
National Hospital Organization Asahikawa Medical Center
🇯🇵Asahikawa, Hokkaido, Japan
National Hospital Organization Mito Medical Center
🇯🇵Higashi-ibaraki-gun, Ibaraki, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Yokohama, Kanagawa, Japan
National Hospital Organization Tokyo National Hospital
🇯🇵Kiyose, Tokyo, Japan
National Hospital Organization Tokyo Medical Center
🇯🇵Meguro-Ku, Tokyo, Japan
National Hospital Organization Disaster Medical Center
🇯🇵Tachikawa, Tokyo, Japan
Japanese Red Cross Okayama Hospital
🇯🇵Okayama, Japan
National Hospital Organization Kochi National Hospital
🇯🇵Kochi, Japan
Saiseikai Fukuoka General Hospital
🇯🇵Fukuoka, Japan
VHS Medical Center
🇰🇷Seoul, Gangdong-gu, Korea, Republic of
The Catholic University of Korea, Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Penang Adventist Hospital
🇲🇾Penang, Malaysia
Ziekenhuis De Gelderse Vallei
🇳🇱Ede, Netherlands
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. Kopernika w Lodzi,
🇵🇱Lodz, Poland
Wojewodzki Szpital Zespolony w Elblagu
🇵🇱Elblag, Poland
Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc w Olsztynie
🇵🇱Olsztyn, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im.Eugenii i Janusza Zeylandow
🇵🇱Poznan, Poland
MRUKMED. Lekarz Beata Madej Mruk i Partner. Sp. p. Oddzial nr 1 w Rzeszowie
🇵🇱Rzeszow, Poland
Samodzielny Publiczny Wojewodzki Szpital Zespolony w Szczecinie Szpital Wojewodzki w
🇵🇱Szczecin-Zdunowo, Poland
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu Szpital Obserwacyjno-Zakazny
🇵🇱Torun, Poland
Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie
🇵🇱Warszawa, Poland
Wojskowy Instytut Medyczny, Klinika Onkologii
🇵🇱Warszawa, Poland
Wojewodzki Szpital Chorob Pluc im. dr Alojzego Pawelca
🇵🇱Wodzislaw-Slaski, Poland
SC Cardio-Center SRL
🇷🇴Craiova, Dolj, Romania
Spitalul Clinic Judetean Mures, radiologie si imagistica medicala
🇷🇴Targu-Mures, Mures, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures, Cardiologie
🇷🇴Targu-Mures, Mures, Romania
SC Oncolab SRL, Oncologie
🇷🇴Craiova, Jud Dolj, Romania
S.C. Oncocenter Oncologie Clinica SRL
🇷🇴Timisoara, Timis, Romania
Medisprof
🇷🇴Cluj Napoca, Romania
SC Hiperdia SA
🇷🇴Cluj-Napoca, Romania
Hiperdia Timisoara, Cardiologie
🇷🇴Timisoara, Romania
S.C. Centrul de Oncologie Sf. Nectarie S.R.L., Oncologie Medicala
🇷🇴Craiova, Romania
SC Radiotherapy Center Cluj SRL
🇷🇴Jud Cluj, Romania
SHI Oncology Dispensary #2 of Health Department of Krasnodar Region
🇷🇺Sochi, Krasnodar Region, Russian Federation
Hiperdia Timisoara, Radiologie si imagistica medicala
🇷🇴Timisoara, Romania
SBHI of Stavropol Region "Essentuki Central City Hospital"
🇷🇺Essentuki, Stavropol Region, Russian Federation
Federal State Budgetary Institution of Healthcare "Clinical Hospital #
🇷🇺Lermontov, Stavropol Region, Russian Federation
SBHI of Stavropol Region "Pyatigorsk Oncology Dispensary"
🇷🇺Pyatigorsk, Stavropol Region, Russian Federation
Stavropol Krai State Budget Healthcare Institute "Stavropol Regional Oncology Clinic"
🇷🇺Stavropol, Stavropol Region, Russian Federation
Chelyabinsk Regional Clinical Oncology Dispensary
🇷🇺Chelyabinsk, Russian Federation
Road Clinical Hospital on the station Chelyabinsk of OJSC "RZD"
🇷🇺Chelyabinsk, Russian Federation
FSBI "N.N.Blokhin Russian Cancer Research Center" RAMS
🇷🇺Moscow, Russian Federation
MRT-Expert, LLC
🇷🇺Chelyabinsk, Russian Federation
P.A.Hertsen Moscow Oncology Research Institute - Branch of the National Medical Radiological
🇷🇺Moscow, Russian Federation
FSBI 'Scientific-Research Oncology Institute n.a. N.N.Petrov' of MoH of RF
🇷🇺Saint-Petersburg, Russian Federation
SPb SBHI "City Clinical Oncology Dispensary"
🇷🇺Saint Petersburg, Russian Federation
Saratov scientific research institute of traumatology and orthopedics
🇷🇺Saratov, Russian Federation
NHI Road clinical hospital at the st. Saratov II of OJSC Russian Railways
🇷🇺Saratov, Russian Federation
Amanzimtoti Oncology Centre
🇿🇦Amanzimtoti, Kwa-zulu Natal, South Africa
Dr Lior Sareli Inc
🇿🇦Cape Town, Western CAPE, South Africa
Hospital Universitario Fundacion Alcorcon
🇪🇸Alcorcon, Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital 12 de Octubre
🇪🇸Madrid, Spain
Hospital Arnau de Vilanova
🇪🇸Valencia, Spain
Hospital Universitario La Paz, Servicio de Oncologia
🇪🇸Madrid, Spain
Consorcio Hospital Universitario General De Valencia
🇪🇸Valencia, Spain
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Chiangrai Prachanukroh Hospital
🇹🇭Muang, Chiang RAI, Thailand
Chula Clinical Research Center
🇹🇭Bangkok, Thailand
Medical Oncology Unit, Department of Medicine, Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Baskent Universitesi Tip Fakultesi Adana Hastanesi
🇹🇷Adana, Turkey
Division of Medical Oncology, Department of Medicine, Faculty of Medicine Siriraj Hospital,
🇹🇭Bangkok, Thailand
Oncology Unit, Department of Medicine, Faculty of Medicine, Naresuan University
🇹🇭Phitsanulok, Thailand
Prachachuen Imaging Center Co., Ltd.
🇹🇭Bangkok, Thailand
Cukurova Universitesi Tip Fakultesi Balcali Hastanesi
🇹🇷Adana, Turkey
Hacettepe Universitesi Tip Fakultesi
🇹🇷Ankara, Turkey
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi
🇹🇷Ankara, Turkey
Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Yildirim Beyazit Universitesi Tip Fakultesi Ataturk Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Yedikule Gogus Hastaliklari ve Gogus Cerrahisi
🇹🇷Istanbul, Turkey
Iyitem Goruntuleme ve Tani Merkezi
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi lc Hastaliklari Anabilim Dali
🇹🇷Izmir, Turkey
Communal Non-Profit Enterprise "Regional Center of Oncology",
🇺🇦Kharkiv, Ukraine
MI 'Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council'
🇺🇦Kryvyi Rih, Ukraine
Poltava Reg. Clinical Oncology Dispensary of PRC, thoracic department, SHEI of Ukr.
🇺🇦Poltava, Ukraine
Lviv State Oncologic Regional Treatment and Diagnostic Center
🇺🇦Lviv, Ukraine
"Central City Clinical Hospital, City Oncology Center, SHEI ""Uzhhorod National University""
🇺🇦Uzhhorod, Ukraine
COT - Centro Oncologico do Triangulo Ltda
🇧🇷Uberlandia, Minas Gerais, Brazil
Chulalongkorn University
🇹🇭Patumwan, Bangkok, Thailand
Hospital Santa Izabel / Santa Casa de Misericordia da Bahia
🇧🇷Salvador, Bahia, Brazil
Hospital Bruno Born (Sociedade Beneficencia e Caridade de Lajeado)
🇧🇷Lajeado, RIO Grande DO SUL, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre - Hospital Santa Rita
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital da Cidade de Passo Fundo - HCPF
🇧🇷Passo Fundo, RIO Grande DO SUL, Brazil
Oncosinos (Lessa Ferreira Servicos Oncologicos Ltda)
🇧🇷Novo Hamburgo, RIO Grande DO SUL, Brazil
Centro de Pesquisa em Oncologia - Uniao Brasileira de Educacao e Assistencia
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Western Health, Sunshine Hospital
🇦🇺St Albans, Victoria, Australia
Instituto Clinico Oncologico del Sur (ICOS)
🇨🇱Temuco, Region DE LA Araucania, Chile
Staedtisches Klinikum Braunschweig gGmbH Institut fuer Roentgendiagnostik und Nuklearmedizin
🇩🇪Braunschweig, Germany
Fachkrankenhaus Coswig GmbH
🇩🇪Coswig, Germany
Institut fuer Diagnostische und Interventionelle Radiologie
🇩🇪Hannover, Germany
University Hospital of Heraklion
🇬🇷Heraklion, Crete, Greece
Matrai Gyogyintezet Pulmonologiai Osztaly
🇭🇺Matrahaza, Hungary
Zala Megyei Korhaz
🇭🇺Zalaegerszeg, Hungary
Holy Cross Hospital
🇺🇸Silver Spring, Maryland, United States
Meritus Center for Clinical Research
🇺🇸Hagerstown, Maryland, United States
Liga Paranaense de Combate ao Cancer - Hospital Erasto Gaertner
🇧🇷Curitiba, Parana, Brazil
Maryland Oncology & Hematology, PA
🇺🇸Wheaton, Maryland, United States
South Coast Radiology, John Flynn Private Hospital
🇦🇺Tugun, Queensland, Australia
Prof Dr Nuri Tenekeci Tani Merkezi
🇹🇷Istanbul, Turkey
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto -
🇧🇷Sao Jose do Rio Preto, SAO Paulo, Brazil
Krankenhaus Martha-Maria Halle-Doelau gGmbH - Apotheke
🇩🇪Halle (Saale), Germany
Viereck-Apotheke
🇩🇪Berlin, Germany
Katholisches Marienkrankenhaus gGmbH
🇩🇪Hamburg, Germany
Cancer Center of Central Connecticut
🇺🇸Southington, Connecticut, United States
Oncoclinic (Clinica de Oncologia e Atendimento de Urgencia Ltda)
🇧🇷Fortaleza, Ceara, Brazil
lnstituto do Cancer do Estado de Sao Paulo - Octavio Frias de -
🇧🇷Sao Paulo, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estadual - IAMSPE/HSPE-FMO
🇧🇷Sao Paulo, Brazil
L'hopital prive du Confluent S.A.S.
🇫🇷Nantes Cedex, France
Hopital d'instruction des armees Sainte Anne
🇫🇷Toulon Cedex 9, France
Klinikum Bayreuth GmbH
🇩🇪Bayreuth, Germany
Holy Cross Hospital Resource Center
🇺🇸Silver Spring, Maryland, United States
Holy Cross Hospital, Hospital Pharmacy
🇺🇸Silver Spring, Maryland, United States
Bradford Hill Centro de Investigaciones Clinicas
🇨🇱Santiago, Region Metropolitana, Chile
Centro Internacional de Estudios Clinicos (CIEC)
🇨🇱Santiago, Region Metropolitana, Chile
Fresenius Kabi Chile, Therapia i.v.
🇨🇱Santiago, Region Metropolitana, Chile
Instituto Clínico Oncológico del Sur (ICOS)
🇨🇱Temuco, Región DE LA Araucanía, Chile
Centre Hospitalier Montbeliard
🇫🇷Montbeliard, France
Krankenhaus Martha-Maria Halle-Doelau gGmbH - Institut fuer Radiologie
🇩🇪Halle (Saale), Germany
Krankenhaus Martha-Maria Halle-Doelau gGmbH
🇩🇪Halle (Saale), Germany
Medizinische Hochschule Hannover Zentralapotheke
🇩🇪Hannover, Germany
Universitaetsklinikum des Saarlandes - Klinik fuer Diagnostische und Interventionelle Radiologie
🇩🇪Homburg/Saar, Germany
Universitaetsklinikum des Saarlandes, Apotheke
🇩🇪Homburg/Saar, Germany
Vincentius-Diakonissen-Kliniken gAG Karlsruhe
🇩🇪Karlsruhe, Germany
Arkana Apotheke OHG
🇩🇪Leipzig, Germany
Tudogyogyintezet Torokbalint
🇭🇺Torokbalint, Hungary
National Hospital Organization Hirosaki National Hospital
🇯🇵Hirosaki, Aomori, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Chungbuk National University Hospital
🇰🇷Cheongju-si, Chungcheongbuk-do, Korea, Republic of
Mount Miriam Cancer Hospital
🇲🇾Tanjung Bungah, Penang, Malaysia
Davao Doctors Hospital
🇵🇭Davao City, Davao DEL SUR, Philippines
Sahyadri Speciality Hospital
🇮🇳Pune, Maharashtra, India
Shatabdi Super Speciality Hospital
🇮🇳Nashik, Maharashtra, India
Klinikum Esslingen GmbH
🇩🇪Esslingen a.N., Germany
St. Elisabethen - Krankenhaus
🇩🇪Frankfurt am Main, Germany
Johannes-Apotheke
🇩🇪Groebenzell, Germany
Univ. of Athens Hosp. of Chest Diseases of Athens ''Sotiria''
🇬🇷Athens, Greece
Euromedica General Clinic of Thessaloniki
🇬🇷Thessaloniki, Greece
European Inter-Balkan Medical Centre
🇬🇷Thessaloniki, Greece
Veszprem Megyei Tudogyogyintezet
🇭🇺Farkasgyepu, Hungary
HealthCare Global Enterprises Limited
🇮🇳Bangalore, Karnataka, India
Unita di Oncologia Toracica
🇮🇹Meldola, FC, Italy
S.C. Oncologia Medica-Presidio Ospedaliero Sondrio
🇮🇹Sondrio, SO, Italy
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of
Nilai Medical Centre
🇲🇾Nilai, Negeri Sembilan, Malaysia
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
UOC Oncologia
🇮🇹Treviglio, BG, Italy
UO Oncologia Medica
🇮🇹Catania, CT, Italy
"SAHI of Moscow ""Moscow City Oncology Hospital #62 of Health Department of Moscow"""
🇷🇺P/o Stepanovskoe, Moscow Region, Russian Federation
Evimed Llc
🇷🇺Chelyabinsk, Russian Federation
SBHI "Regional clinical hospital #2" of MoH of Krasnodar Region
🇷🇺Krasnodar, Russian Federation
LLC "Medical clinic "INNOVACIA", chemotherapy department
🇺🇦Lyutizh, KYIV Region, Ukraine
MI 'City Dnipropetrovsk Multi-field Clin. Hospital #4 of DRC', Dep.-nt of Chemotherapy;
🇺🇦Dnipropetrovsk, Ukraine
Cape Town Oncology Trials (Pty) Ltd
🇿🇦Kraaifontein, Western CAPE, South Africa
Hirsch-Apotheke
🇩🇪Leer, Germany
Onkologie UnterEms
🇩🇪Leer, Germany
Onkologie Moers GbR
🇩🇪Moers, Germany
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendelointezet, Megyei Onkologiai Kozpont
🇭🇺Szolnok, Hungary
UOC Oncologia Medica
🇮🇹Legnago, VR, Italy
National Hospital Organization Himeji Medical Center
🇯🇵Himeji, Hyogo, Japan
Centrul Medical Pozimed, SC Pozitron Medical Investigation SRL
🇷🇴Constanta, Romania
State Budget Healthcare Institution of Arkhangelsk Region
🇷🇺Arkhangelsk, Russian Federation
Drs Schnetler, Corbett and Partners Inc
🇿🇦Cape Town, Western CAPE, South Africa
SBEI HPE RyazSMU of MoH of Russia based on SBI of Ryazan Region
🇷🇺Ryazan, Russian Federation
Limited Liability Company "Common health"
🇷🇺Sochi, Russian Federation
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Mahatma Gandhi Cancer Hospital And Research Institute
🇮🇳Visakhapatnam, Andhra Pradesh, India
UOSD Pneumologia Oncologica - Padiglione Flaiani
🇮🇹Roma, RM, Italy
National Hospital Organization Mie Chuo Medical Center
🇯🇵Tsu, MIE, Japan
National Hospital Organization Sendai Medical Center
🇯🇵Sendai, Miyagi, Japan
National Hospital Organization Oita Medical Center
🇯🇵Oita, Japan
Klinisch Chemisch en Hematologisch Laboratorium (KCHL)
🇳🇱Arnhem, Netherlands
Spitalul Clinic Municipal
🇷🇴Cluj-Napoca, Romania
Chelyabinsk Regional Hospital
🇷🇺Chelyabinsk, Russian Federation
Privolzhskiy District Medical Center of Federal Biomedical Agency
🇷🇺Nizhniy Novgorod, Russian Federation
Clinical Research Center, Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Euromed Goruntuleme ve Tani Merkezi
🇹🇷Istanbul, Turkey
"RMI ""Sumy Reg. Clin. Oncology Dispensary"". oncothoracic dep.-nt. Surny State Univ.,
🇺🇦Sumy, Ukraine
Vinnytsia Regional Clinical Oncology Dispensary
🇺🇦Vinnytsia, Ukraine
Rijnstate Ziekenhuis
🇳🇱Arnhem, Netherlands
Cebu Doctors' University Hospital
🇵🇭Cebu City, Cebu, Philippines
Spitalul Clinic Judetean de Urgenta "Sf Apostol Andrei" Constanta Clinica Oncologie Medicala
🇷🇴Constanta, Romania
Dr's Grineva Private Clinic
🇷🇺Sochi, Krasnodar Region, Russian Federation
S.G. Primushko Republican Clinical Oncology Dispensary
🇷🇺Izhevsk, Udmurt Republic, Russian Federation
"SBHI ""Chelyabinsk Regional Clinical Oncology Dispensary"""
🇷🇺Chelyabinsk, Russian Federation
SBHI NR Clinical Diagnostic Center
🇷🇺Nizhniy Novgorod, Russian Federation
SBHI of NNR Nizhniy Novgorod Regional Oncology Dispensary
🇷🇺Nizhniy Novgorod, Russian Federation
Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari
🇹🇷Istanbul, Turkey
"Municipal Institution ""Chernivtsi Regional Clinical Oncology Dispensary"",
🇺🇦Chernivtsi, Ukraine
SPAD Imaging International S.R.L
🇷🇴Craiova, Dolj, Romania
Spitalul Clinic Judetean Mures, sectia Clinica de Oncologie Medicala
🇷🇴Targu-Mures, Mures, Romania
"RBHI ""Kursk Regional Clinical Oncology Dispensary"" of Healthcare Committee of Kursk Region"
🇷🇺Kislino Steading Of Kursk Region, Ryshkovskiy Village Council, Russian Federation
SBHI of Vladimir Region "Regional Clinical Oncology Dispensary"
🇷🇺Vladimir, Vladimir Region, Russian Federation
SBHI "Chelyabinsk Regional Clinical Hospital"
🇷🇺Chelyabinsk, Russian Federation
"Budgetary Healthcare Institution of Omsk Region ""Clinical Oncology Dispensary"""
🇷🇺Omsk, Russian Federation
Clinical hospital n.a. S.R. Mirotvortseva of SSMU
🇷🇺Saratov, Russian Federation
Hospital Son Llatzer
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Istanbul Universitesi Onkoloji Enstitusu
🇹🇷Istanbul, Turkey
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
Southern Cancer Center, PC
🇺🇸Mobile, Alabama, United States
Swedish Covenant Hospital
🇺🇸Chicago, Illinois, United States
Elkerliek Ziekenhuis
🇳🇱Helmond, Netherlands
Cardiac Services, John Flynn Private Hospital -
🇦🇺Tugun, Queensland, Australia
Austin Health - Olivia Newton - John Cancer & Wellness Centre
🇦🇺Heidelberg, Victoria, Australia
Instituto Joinvillense de Hematologia e Oncologia SS Ltda - Clinica de Hematologia e Oncologia
🇧🇷Joinville, Santa Catarina, Brazil