Investigating gastric emptying rate of cow milk by means of MRI in people that either do or do not experience gastrointestinal discomfort after milk ingestion.

Completed

• Conditions: fysiologie; Difference in gastric digestion of cow milk between people who do or do not experience abdominal discomfort

• Registration Number: NL-OMON46025
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Drinking cow milk (maximum of 200ml/week for those who declare to not drink habitually and a minimum of 700ml/week for those who declare to drink cow milk habitually)
Reporting/not reporting GI discomfort after cow milk consumption (depending on study group)
Female
BMI: 18.5 - 30 kg/m2
Age: 18 - 60 years
Healthy (self-reported)
Need to be willing to be informed about incidental findings of pathology

Exclusion Criteria

Having a history of medical or surgical events related to the GI tract that may give rise to GI complaints
Medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc.
Medical drug use that influence the GI tract*s microbiota: antibiotic use within 1 months prior to the pre-study screenings day
Mental status that is incompatible with the proper conduct of the study
Daily use of probiotics
Weekly use of laxatives
Lactose intolerance (medically diagnosed or tested with a lactose breath test in screening visit) and cow milk allergy
Reported unexplained weight loss or weight gain of > 5 kg in the month prior to screening
Reported slimming or medically prescribed diet
Reported vegan or macrobiotic life-style
Alcohol consumption of more than 14 glasses/week
Smoking more than 4 cigarettes a day
Not willing to give stool sample during the study
Being pregnant, having the intention to get pregnant, lactating or being under postmenopausal hormonal treatment
Not having a general practitioner
Having a contra-indication to MRI scanning

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Gastric emptying half-time based on gastric content (volume in mL) over time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Subjective GI symptoms, wellbeing, thirst and appetite.</p><br>