Investigating gastric emptying of cow milk in healthy subjects, who either do or do not experience gastro-intestinal discomfort after cow milk ingestio

Withdrawn

• Conditions: Fysiologie; Difference in gastric digestion between cow milk consumers that do or do not experience abdominal discomfort

• Registration Number: NL-OMON46478
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Drinking cow milk (maximum of 200ml/week for those who declare to not drink milk habitually and a minimum of 700ml/week for those who declare to drink milk habitually)
Do report/do not report GI discomfort after milk consumption (depending on study group)
Not lactose intolerant (tested with lactose breath test)
Female
BMI:18.5 * 30 kg/m2
Age: 18 - 60 years
Healthy (self-reported)
Having given informed consent
Need to be willing to be informed about incidential findings of pathology

Exclusion Criteria

Having a history of medical or surgical events related to the GI tract that may give rise to GI complaints
Medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc.
Medical drug use that influence the GI tract*s microbiom: antibiotic use within 1 months prior to the pre-study screenings day
Daily consumption of probiotics
Weekly use of laxatives
Lactose intolerance (medically diagnosed) and cow milk allergy
Reported unexplained weight loss or weight gain of > 5 kg in the month
Reported slimming or medically prescribed diet, vegan or macrobiotic life-style
Alcohol consumption of more than 14 glasses/week
Smoking more than 4 cigarettes a day
Being pregnant, having the intention to get pregnant, lactating or being under postmenopausal hormonal treatment
Not having a general practitioner
Having a contra-indication to MRI scanning

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Gastric emptying half-time (t50) derived from gastric content (volume in mL)<br /><br>over time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Subjective GI symptoms, thirst and appetite.</p><br>