A study compares the effects of Dexmedetomidine administered via trachea versus vein on recovery process and peri-extubation cough prevention. Patients and evaluators remain unaware of treatment assignment
Phase 3
- Conditions
- Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis
- Registration Number
- CTRI/2024/05/067165
- Lead Sponsor
- Dr S N Medical college
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Individuals of both genders aged between 18 and 60 years, with a weight falling within the range of 40 to 80 kg with physical status American Society of Anaesthesiologists (ASA) I and II, undergoing elective abdominal surgery under general anaesthesia will be included.
Exclusion Criteria
1) Long term use of sedative drugs (benzodiazepines, barbiturates),
2) Anticipated difficult airway,
3) Those who received alpha2 agonists preoperatively,
4) Patients who were transferred to open surgery during the operation were excluded from the final analysis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will include severity of cough at extubation assessed by 4 point cough scaleTimepoint: 0 minutes, 2 minutes, 5 minutes, 15 minutes, 30 minutes post extubation
- Secondary Outcome Measures
Name Time Method Monitoring of hemodynamic parametersTimepoint: 5 min before anaesthesia(T0), immediately after administration of dexmedetomidine(T1), 5 min after DEXMEDETOMIDINE(T2), 10 min after DEXMEDETOMIDINE(T3), at end of surgery(T4), at awareness(T5), at extubation(T6), 2 min after extubation(T7), 5 min after extubation(T8), 15 min after extubation(T9), 30 min after extubation(T10)