Effect of remote ischemic conditioning on pain-free walking distance and angiogenesis in patients with chronic arterial occlusive disease.
- Conditions
- I70.29
- Registration Number
- DRKS00025735
- Lead Sponsor
- niversitätsklinikum Schleswig-Holstein Campus Kiel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
paVk stage IIb;
- written informed consent
- Age <18 years; >75 years
- Current participation in another clinical intervention study
- Participation in another clinical intervention study within the last 30 days
-Cognitive/language barriers, comprehension problems during the educational process
- Severe renal and hepatic insufficiency
- Severe COPD (FeV1= 50%).
- Existing drug and alcohol abuse
- Neurological diseases (Parkinson's disease, multiple sclerosis, epilepsy, Alzheimer's disease)
- Acute infections
- Diabetes mellitus
- Pronounced pAVK of the upper extremities
- Polyneuropathy of the upper extremities
- Arterio-venous fistula (shunt) or lymphedema of the upper extremities
- Myocardial infarction < 2 months
- Stroke < 2 months
- Malignancy
- Pregnancy
- Lack of compliance, >3 missed RIC applications.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain-free and total walking distance determined using the standardized treadmill test
- Secondary Outcome Measures
Name Time Method (1)Does RIC lead to improved microcirculation of the affected extremities (measured by thermal imaging camera)?<br>(2)Does RIC lead to an improvement in quality of life (SF-36 quality of life questionnaire)?<br>(3)What is the impact of RIC on renal function?<br>(4)Does long-term RIC change the activity of atherosclerotic inflammatory response (Il-1,Il-6, hs-CRP, fibrinogen)?<br>(5)Do molecular and protein biochemical changes in serum and tissue samples occur as a result of RIC? <br>(6)Does RIC increase the number of endothelial progenitor cells in the blood.<br><br>Translated with www.DeepL.com/Translator (free version)