Role of Biomarkers to Screen for Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- Validity of biomarkers to screen for obstructive sleep apnea
研究概览
简要总结
assess the relationship between obstructive sleep apnea and endocrine, inflammatory, and metabolic bio-markers in consecutively enrolled adult male patients with a clinical suspicion of obstructive sleep apnea.
详细描述
Obstructive sleep apnea (OSA) is a disorder with high prevalence, estimated to occur in 34% of men and 17% of women , afflicting more than 100 million adults worldwide.
OSA is the third most common serious respiratory condition after Asthma and COPD.
Patients with untreated OSA are at increased risk for hypertension, cardiovascular disease, heart failure, stroke, obesity, metabolic dysregulation, diabetes mellitus, daytime sleepiness, depression, accidents and are a significant burden on the healthcare system.
Unfortunately, up to 90% of individuals with OSA remain without a diagnosis or therapy.
The association between OSA and adverse health consequences has led the American Heart Association and others to suggest that OSA screening be integrated into routine clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with a clinical suspicion of obstructive sleep apnea enrolled to the investigator's chest department.
排除标准
- •Patients who previously treated as obstructive sleep apnea, or receiving opioid pain medications.
结局指标
主要结局
Validity of biomarkers to screen for obstructive sleep apnea
时间窗: baseline
analysis of biomarkers results (which include Pentraxin 3, HbA1C,Uric acid,CRP,ESR,Plasma fibrinogen) will be assessed and compared to the results of polysymnography
次要结局
- Inflammatory biomarker level in OSA patients compared to controls(baseline)
研究者
Ali Abuzaid Ali
Principal Investigator
Assiut University