The effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants on TOLerance
Completed
- Conditions
- Premature infantsNeonatal Diseases
- Registration Number
- ISRCTN42413683
- Lead Sponsor
- Erasmus Medical Centre (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 250
Inclusion Criteria
1. Admission to neonatal intensive care unit within 24 hours after birth
2. Gestational age under 32 weeks
3. Birth weight less than 1750 g
Exclusion Criteria
1. Simultaneous participation in another trial of which the intervention may influence this trials endpoints
2. Congenital gastrointestinal obstructions like duodenal atresia, anal atresia, etc.
3. Any disease entity known to encompass impaired growth other than small gestational age
4. No informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the effect on both feeding regimes on feeding tolerance. Primary objective is days to reach full enteral feedings, defined as more than or equal to 120 mL/kg/d.
- Secondary Outcome Measures
Name Time Method 1. Secondary objective is number of feeding interruptions, days on total parenteral nutrition and number of apnea episodes per day<br>2. To assess somatic growth in both feeding regimes. To evaluate this variable, the following items will be used: days to regain birth weight, rates of weight gain, knemometry and head circumference<br>3. To assess complications in both groups measured as catheter related sepsis and necrotising enterocolitis