SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)

Recruiting

• Conditions: SARS-CoV Infection

• Registration Number: NCT04750356
• Lead Sponsor: University College, London

Brief Summary

The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients.

Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives and serum from the Crick COVID-19 Consortium Testing centre (Cohort A1) and additional biological material collected prospectively (Cohorts A2 and B) will be used for research into SARS-CoV-2 transmission, evolution and immune control. This testing centre is a partnership between UCLH and The Francis Crick Institute to provide COVID 19 RT PCR testing for healthcare workers (HCWs) and patients in London Hospitals and care homes. A third group (Cohort C) of the study will allow for collaborative work with other REC approved research studies that have used the Crick COVID-19 Consortium Testing centre and will involve the use of study samples already collected from each study to be analysed under the SARS-CoV-2 Longitudinal Study end points

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-27
• Study First Submitted: 2021-01-28
• Study First Submitted QC: 2021-02-10
• Study First Posted: 2021-02-11
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-20
• Last Update Posted: 2022-05-23
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

• Individuals who have previously provided nasal throat swab samples for SARS-CoV-2 testing at the Crick COVID 19 Consortium Testing centre.
• ≥18 years of age
• To enrol in the SARS-CoV-2 positive cohort of the study, the participant should have a positive RT qPCR result
• Employees based at the participating sites including who had their serology and/or swab tested (for recruitment to Cohort B)
• Participants enrolled in other studies who had their samples processed by using the Crick COVID 19 Consortium Testing centre (for recruitment to Cohort C).
• Written informed consent (except Cohort A1)

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SARS-CoV-2 susceptibility in healthcare workers and patients	24 months	To investigate SARS-CoV-2 susceptibility by examining the number of positive SARS-CoV-2 result per participant
SARS-CoV-2 transmission in healthcare workers and patients	24 months	To investigate SARS-CoV-2 transmission by analysis of samples sequencing data from each study centre and across study centres
SARS-CoV-2 severity in healthcare workers and patients	24 months	To investigate SARS-CoV-2 severity by review of any hospital admissions

Trial Locations

Locations (3)

Ealing and Northwick Park hospital; 🇬🇧 London, United Kingdom

UCLH; 🇬🇧 London, United Kingdom

The Francis Crick Institute; 🇬🇧 London, United Kingdom