Relationship Between Serum Markers and Motor Recovery and Ambulation in Post-stroke Patients

Completed

• Conditions: Stroke; Biomarkers; Serum Magnesium; Serum Vitamin D; Serum Uric Acid

• Registration Number: NCT07086092
• Lead Sponsor: Abant Izzet Baysal University

Brief Summary

This study aim to retrospectively investigate the effects of the magnesium, vitamin D, and uric acid serum markers on motor recovery and ambulation in post-stroke patients.

Detailed Description

Stroke is the sudden loss of neurological function associated with a reduction or cessation of blood flow in the brain, resulting from the blockage or rupture of cerebral vessels. Stroke is the second leading cause of death and the third leading cause of disability worldwide. Regaining motor recovery and ambulation skills in patients is one of the main goals of rehabilitation. It is critical for patients to improve their quality of life and regain their independence. Serum biochemical markers can be used to predict post-stroke recovery. Serum magnesium, vitamin D, and uric acid are biochemical markers that may play a role in the recovery process of stroke patients.

This study aim to retrospectively investigate the effects of the magnesium, vitamin D, and uric acid serum markers on motor recovery and ambulation in post-stroke patients.

Study Timeline

• Status Verified: 2025-07
• Study Start: 2025-07-15
• Primary Completion: 2025-07-15
• Study Completion: 2025-07-15
• Study First Submitted: 2025-07-18
• Study First Submitted QC: 2025-07-18
• Study First Posted: 2025-07-25
• Last Update Submitted: 2025-07-25
• Last Update Posted: 2025-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 257

Inclusion Criteria

• Patients who had a single stroke between 2019 and 2024
• Patients who were admitted to the rehabilitation ward and had their serum vitamin D, magnesium, and uric acid levels measured
• Patients whose functional ambulation scale scores and Brunnstrom motor recovery stages were recorded

Exclusion Criteria

• Patients with other neurological diseases
• Patients with multiple strokes
• Patients with gout, renal failure, or hyperparathyroidism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum magnesium levels	Before treatment	Serum magnesium levels measured before the patients' rehabilitation will be obtained from past medical records.
Serum uric acid levels	Before treatment	Serum uric acid levels measured before the patients' rehabilitation will be obtained from past medical records.
Serum vitamin D levels	Before treatment	Serum vitamin D levels measured before the patients' rehabilitation will be obtained from past medical records.
Brunnstrom Motor Recovery Stage	Before treatment	Brunnstrom stages is a scale used to assess motor recovery after a stroke, which is expressed using values between 1 and 6. The higher the value on this scale, the higher would be the recovery. Brunnstrom Motor Recovery Stages measured before the patients' rehabilitation will be obtained from past medical records.
Functional Ambulation Classification	Before treatment	Functional Ambulation Classification is a 6-point functional walking test that evaluates ambulation ability and determines the amount of human support required by patients while walking, regardless of whether they use a personal assistive device. A score of 0 indicates that the patient has a dysfunctional ambulation A score of 5 denotes independent ambulation on any surface. Functional Ambulation Classification Stages measured before the patients' rehabilitation will be obtained from past medical records.

Trial Locations

Locations (1)

Abant Izzet Baysal University; 🇹🇷 Bolu, Turkey